Socioeconomic influences on survival outcome in idh-wildtype glioma patients: examining the role of age, education, and lifestyle factors.

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2025-06-27 DOI:10.1007/s00701-025-06594-5

Matthias Demetz, Aleksandrs Krigers, Julia Klingenschmid, Claudius Thomé, Christian F Freyschlag, Johannes Kerschbaumer

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引用次数: 0

Abstract

Background: Socioeconomic factors influence survival in different cancer types. This study aimed to assess the impact of various socioeconomic factors, including education, marital status, lifestyle, and social network, on survival in patients with Isocitrate dehydrogenase (IDH) wildtype gliomas.

Methods: We conducted a retrospective analysis of 309 adult patients with de novo diagnosed IDH wildtype gliomas who underwent surgical treatment at our institution between 2014 and 2022. Socioeconomic factors, including education, marital status, employment, language, lifestyle (alcohol abuse, smoking, BMI), and social network were assessed. Progression-free survival (PFS) and overall survival (OS) were analyzed using Kaplan-Meier and Cox regression models.

Results: Education, alcohol abuse, and age significantly influenced OS. Patients with higher education had significantly lower tumor volumes (p = 0.037) and longer survival (p = 0.001). Alcohol abuse was associated with significantly shorter OS (8.6 vs. 17.9 months, p = 0.034). Patients aged over 65 years showed significantly shorter OS in this study (14.9 months vs 33.2 months, p < 0.001). Native and non-native German speakers had similar outcomes. Marital status did not significantly affect survival.

Conclusion: Socioeconomic and lifestyle factors, especially higher education and alcohol abuse, significantly impact survival in IDH wildtype glioma patients. These findings suggest that, in addition to molecular features and oncological treatment, socioeconomic and lifestyle factors also play a crucial role in influencing the prognosis of patients with IDH wildtype gliomas.

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社会经济因素对idh-野生型胶质瘤患者生存结局的影响：年龄、教育和生活方式因素的影响

背景：社会经济因素影响不同癌症类型的生存。本研究旨在评估各种社会经济因素，包括教育、婚姻状况、生活方式和社会网络，对异柠檬酸脱氢酶（IDH）野生型胶质瘤患者生存的影响。方法：我们对2014年至2022年在我院接受手术治疗的309例新发IDH野生型胶质瘤成年患者进行回顾性分析。社会经济因素，包括教育、婚姻状况、就业、语言、生活方式（酗酒、吸烟、体重指数）和社会网络进行了评估。采用Kaplan-Meier和Cox回归模型分析无进展生存期（PFS）和总生存期（OS）。结果：教育程度、酒精滥用和年龄对OS有显著影响。高学历患者肿瘤体积显著降低（p = 0.037），生存期显著延长（p = 0.001）。酒精滥用与较短的生存期相关（8.6个月对17.9个月，p = 0.034）。在本研究中，65岁以上患者的生存期明显缩短（14.9个月vs 33.2个月）。结论：社会经济和生活方式因素，特别是高等教育和酗酒，显著影响IDH野生型胶质瘤患者的生存。这些发现表明，除了分子特征和肿瘤治疗外，社会经济和生活方式因素在影响IDH野生型胶质瘤患者的预后中也起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.