Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs

IF 7.9 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical and Translational Medicine Pub Date : 2025-06-27 DOI:10.1002/ctm2.70354

Jie Ji, Dandan Jin, Junpeng Zhao, Xudong Xie, Yujie Jiao, Xuyang He, Yuxuan Huang, Lirong Zhou, Mingbing Xiao, Xiaolei Cao

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Abstract

Pancreatic cancer (PC) is an extremely deadly type of cancer, and the 5-year survival rate remains less than 10%. The tumour microenvironment (TME) affects the occurrence, progression and treatment outcomes of PC. MicroRNAs (miRNAs) are essential to regulate PC TME. This review delves into the different roles of miRNAs in the PC TME, including exosome communication, angiogenesis, interactions with cancer-associated fibroblasts, the immunological and neuronal microenvironments and metabolic reprogramming. However, research on the complex regulatory networks and synergistic effects of miRNAs in the TME is still insufficient, and their clinical translation and application face challenges. This review summarised the activities of miRNAs in the PC TME, guiding future research and therapeutic strategies involving miRNAs in PC. Future studies should integrate advanced technologies to decode the spatiotemporal dynamics of miRNA regulation within the TME and develop optimised nanodelivery systems for stable and targeted miRNA delivery, advancing clinical applications in PC treatment.

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解读胰腺癌微环境：microrna的多方面调控

胰腺癌（PC）是一种极其致命的癌症，其5年生存率仍低于10%。肿瘤微环境（tumor microenvironment， TME）影响PC的发生、发展和治疗结果。microrna （mirna）是调控PC TME的关键。这篇综述深入探讨了mirna在PC TME中的不同作用，包括外泌体通讯、血管生成、与癌症相关成纤维细胞的相互作用、免疫和神经元微环境以及代谢重编程。然而，对TME中mirna复杂的调控网络和协同效应的研究仍然不足，其临床翻译和应用面临挑战。本文综述了mirna在PC TME中的活性，为未来的研究和治疗策略提供指导。未来的研究应该整合先进的技术来解码TME中miRNA调控的时空动态，并开发优化的纳米递送系统，以实现稳定和靶向的miRNA递送，推进PC治疗的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Medicine Multiple-

CiteScore

15.90

自引率

1.90%

发文量

450

审稿时长

4 weeks

期刊介绍： Clinical and Translational Medicine (CTM) is an international, peer-reviewed, open-access journal dedicated to accelerating the translation of preclinical research into clinical applications and fostering communication between basic and clinical scientists. It highlights the clinical potential and application of various fields including biotechnologies, biomaterials, bioengineering, biomarkers, molecular medicine, omics science, bioinformatics, immunology, molecular imaging, drug discovery, regulation, and health policy. With a focus on the bench-to-bedside approach, CTM prioritizes studies and clinical observations that generate hypotheses relevant to patients and diseases, guiding investigations in cellular and molecular medicine. The journal encourages submissions from clinicians, researchers, policymakers, and industry professionals.