FBH1 and the replication stress response: Implications for genome stability and cancer development

IF 3 3区生物学 Q2 GENETICS & HEREDITY

DNA Repair Pub Date : 2025-06-26 DOI:10.1016/j.dnarep.2025.103865

Joshua L. Turner, Jennifer M. Mason

引用次数: 0

Abstract

The replication stress response plays important roles in maintaining genome stability.In this review article, we focus on the role of FBH1 in the replication stress response and promoting death in cells with excessive DNA damage. FBH1-deficiency results in resistance to replication stress. We discuss how loss and gain of FBH1 in a wide variety of cancers can contribute to tumor-associated phenotypes, impact cancer therapies and be exploited for potential targeted therapies.

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FBH1和复制应激反应：对基因组稳定性和癌症发展的影响

复制应激反应在维持基因组稳定性中起着重要作用。在这篇综述文章中，我们重点关注FBH1在复制应激反应和促进过度DNA损伤细胞死亡中的作用。fbh1缺乏导致对复制胁迫的抗性。我们讨论了各种癌症中FBH1的缺失和获得如何促进肿瘤相关表型，影响癌症治疗并被用于潜在的靶向治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

DNA Repair 生物-毒理学

CiteScore

7.60

自引率

5.30%

发文量

审稿时长

59 days

期刊介绍： DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease. DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.