Effects of Dexmedetomidine on Acute Kidney Injury and Perioperative Outcomes in Aortic Vascular Surgery: A Systematic Review and Meta-Analysis.

IF 1.1 Q3 ANESTHESIOLOGY
Tallal Mushtaq Hashmi, Hadiah Ashraf, Muhammad Burhan, Rohma Zia, Mushood Ahmed, Raheel Ahmed, Majid Toseef Aized
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引用次数: 0

Abstract

Background: Dexmedetomidine, a highly selective α2-adrenergic receptor agonist, may help mitigate postoperative complications in patients undergoing aortic vascular surgery. Methodology: A comprehensive search was conducted across PubMed, the Cochrane Library, and Embase to identify studies assessing the efficacy and safety of dexmedetomidine compared with placebo in patients undergoing aortic vascular surgery. A random effects meta-analysis was performed with R version 4.4.1 using the "meta" package. Results: Our analysis included eleven studies, comprising eight RCTs and three cohort studies, with a combined total of 1731 patients. The results showed that dexmedetomidine significantly reduced acute kidney injury (OR 0.49, 95% CI 0.25 to 0.98), ICU length of stay (MD -0.25 days, 95% CI -0.47 to -0.02), postoperative pulmonary complications (OR 0.55, 95% CI 0.32 to 0.94), and CRP levels 24 h post-surgery (MD -24.73 mg/L, 95% CI -46.29 to -3.16) compared to the control group. The length of hospital stay (MD -0.87 days, 95% CI -2.57 to 1.01), postoperative delirium (OR 0.78, 95% CI 0.43 to 1.42), and in-hospital mortality (OR 0.57, 95% CI 0.29 to 1.12) were not significantly different between the two groups. Conclusion: In patients undergoing aortic vascular surgery, dexmedetomidine administration is associated with reduced acute kidney injury, length of ICU stay, postoperative pulmonary complications, and CRP levels 24 h post-surgery.

右美托咪定对主动脉血管手术急性肾损伤和围手术期预后的影响:系统回顾和荟萃分析。
背景:右美托咪定是一种高选择性α2-肾上腺素能受体激动剂,可能有助于减轻主动脉血管手术患者的术后并发症。方法:通过PubMed、Cochrane图书馆和Embase进行了全面的检索,以确定评估右美托咪定与安慰剂在主动脉血管手术患者中的疗效和安全性的研究。随机效应荟萃分析采用R 4.4.1版本,使用“meta”软件包。结果:我们的分析包括11项研究,包括8项随机对照试验和3项队列研究,共计1731例患者。结果显示,与对照组相比,右美托咪定显著降低急性肾损伤(OR 0.49, 95% CI 0.25 ~ 0.98)、ICU住院时间(MD -0.25天,95% CI -0.47 ~ -0.02)、术后肺部并发症(OR 0.55, 95% CI 0.32 ~ 0.94)和术后24 h CRP水平(MD -24.73 mg/L, 95% CI -46.29 ~ -3.16)。两组住院时间(MD -0.87天,95% CI -2.57 ~ 1.01)、术后谵妄(OR 0.78, 95% CI 0.43 ~ 1.42)和住院死亡率(OR 0.57, 95% CI 0.29 ~ 1.12)无显著差异。结论:在接受主动脉血管手术的患者中,右美托咪定可减少急性肾损伤、ICU住院时间、术后肺部并发症和术后24 h CRP水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.60
自引率
14.30%
发文量
31
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