[Uric acid and skeletal muscle status in females with rheumatoid arthritis].

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Terapevticheskii Arkhiv Pub Date : 2025-06-08 DOI:10.26442/00403660.2025.05.203215

O V Dobrovolskaya, M V Kozyreva, N V Demin, N V Toroptsova

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引用次数: 0

Abstract

Aim: To study the association of uric acid (UA) levels with skeletal muscle mass, strength and physical performance in women with rheumatoid arthritis (RA).

Materials and methods: One hundred thirty women (median age 61 [53; 66] years) with confirmed RA who signed informed consent were examined. A clinical and laboratory examination was performed, including an assessment of muscle strength, physical performance. Dual-energy X-ray absorptiometry according to the "whole body" program was done.

Results: The median UA level was 262.8 [197.4; 310.5] μmol/l, the incidence of hyperuricemia was 9.2%. Positive correlations of UA with the total lean mass index (r=0.32; p<0.001), appendicular lean mass index (r=0.24; p=0.006) were established. These associations were confirmed in multiple linear regression analysis (b*=0.38; p<0.001 and b*=0.29; p<0.001, respectively). There was no association between the level of UA and RA parameters (duration of the disease, glucocorticoid intake, RF and ACCP seropositivity, ESR, CRP and DAS-28 index), as well as with muscle strength. A negative correlation between the level of UA and parameters of physical performance was found.

Conclusion: The frequency of hyperuricemia was 9.2% in women with RA. Multiple regression analysis confirmed an independent association between lean mass and UA level.

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[女性类风湿关节炎患者的尿酸和骨骼肌状况]。

目的：研究类风湿关节炎（RA）患者尿酸（UA）水平与骨骼肌质量、力量和体能表现的关系。材料和方法：130名女性(中位年龄61 [53；[66]年)确诊RA，并签署知情同意书。进行了临床和实验室检查，包括肌肉力量和身体表现的评估。根据“全身”程序进行双能x射线吸收测定。结果：UA中位数为262.8 [197.4；310.5] μmol/l，高尿酸血症发生率为9.2%。UA与总瘦体重指数呈正相关(r=0.32；P0.001)，阑尾瘦质量指数(r=0.24；P =0.006)。这些关联在多元线性回归分析中得到证实(b*=0.38；P0.001, b*=0.29；分别为p0.001)。UA水平与RA参数（病程、糖皮质激素摄入量、RF和ACCP血清阳性、ESR、CRP和DAS-28指数）以及肌肉力量之间无相关性。UA水平与体能参数呈负相关。结论：女性RA患者高尿酸血症发生率为9.2%。多元回归分析证实瘦体重与UA水平之间存在独立的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Terapevticheskii Arkhiv 医学-医学：内科

CiteScore

1.40

自引率

33.30%

发文量

171

审稿时长

3-8 weeks

期刊介绍： Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.