[Trends in the prevalence of Helicobacter pylori infection among adults in Moscow: a systematic review and meta-analysis].

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Terapevticheskii Arkhiv Pub Date : 2025-06-08 DOI:10.26442/00403660.2025.05.203250

D N Andreev, A R Khurmatullina, D S Bordin, I V Maev

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引用次数: 0

Abstract

Aim: To systematize data on the trends of the prevalence of Helicobacter pylori infection among the Moscow adult population.

Materials and methods: The MEDLINE/PubMed, EMBASE, Google Scholar, and the Russian Science Citation Index were searched for studies published between January 1, 1985, and February 7, 2025, inclusive. Publications were selected based on an analysis of their titles and abstracts. Included were peer-reviewed publications in Russian and English containing data on the prevalence of H. pylori among the adult population of Moscow, studies using validated methods for the diagnosis of H. pylori based on serological, urease respiratory tests, histological and molecular methods, as well as publications containing detailed statistical processing of data suitable for inclusion in the meta-analysis.

Results: The final analysis included seven studies totaling 7,581 subjects (the overall mean age of all subjects was 48.28±13.20 years). The overall prevalence of H. pylori infection in the adult population of Moscow in the analyzed pool of studies for 18 years (2006-2024) was 66.534% (95% confidence interval [CI] 42.097-86.989), including 78.661% (95% CI 59.400-92.910) when using serological diagnostic methods and 48.473% (95% CI 32.331-64.781) when using the ¹³C-urease respiratory test. Studies conducted before 2015 showed the prevalence of H. pylori infection of 81.294% (95% CI 67.202-92.109), 68.028% (95% CI 29.383-95.895) in 2015-2020, and 39.860% (95% CI 33.993-45.877) after 2020. The meta-regression analysis revealed a statistically significant decrease in the prevalence of H. pylori depending on the year of the study (regression coefficient for the year -4.22 (95% confidence interval -6.27--2.17; p<0,0099).

Conclusion: The meta-analysis showed a gradual regression in the prevalence of H. pylori infection in Moscow, the largest metropolis in Russia and Europe. However, infection prevalence in the adult population remains relatively high, supporting the need for continued programs of timely diagnosis of H. pylori and subsequent eradication therapy to reduce the risk of associated diseases.

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[莫斯科成年人幽门螺杆菌感染流行趋势：系统回顾和荟萃分析]。

目的：整理莫斯科成人幽门螺杆菌感染流行趋势。材料和方法：检索MEDLINE/PubMed、EMBASE、谷歌Scholar和Russian Science Citation Index，检索1985年1月1日至2025年2月7日（含）发表的研究。出版物的选择是基于对其标题和摘要的分析。纳入了同行评审的俄文和英文出版物，其中包含莫斯科成年人群中幽门螺杆菌患病率的数据，使用基于血清学、脲酶呼吸测试、组织学和分子方法的有效幽门螺杆菌诊断方法的研究，以及包含适合纳入meta分析的数据的详细统计处理的出版物。结果：最终纳入7项研究，共计7581例受试者（所有受试者的总体平均年龄为48.28±13.20岁）。在分析的18年（2006-2024）研究池中，莫斯科成年人群幽门螺杆菌感染的总体患病率为66.534%(95%可信区间[CI] 42.097-86.989)，其中血清学诊断方法为78.661% (95% CI 59.400-92.910)， 13c -脲酶呼吸试验为48.473% （95% CI 32.331-64.781）。2015年前的研究显示，2015-2020年幽门螺杆菌感染率为81.294% (95% CI 67.202-92.109)， 2015-2020年为68.028% (95% CI 29.383-95.895)， 2020年后为39.860% （95% CI 33.993-45.877）。meta回归分析显示，幽门螺杆菌的患病率在统计学上显著下降，这取决于研究的年份（回归系数为-4.22）(95%置信区间为-6.27—2.17；结论：荟萃分析显示，俄罗斯和欧洲最大的大都市莫斯科的幽门螺杆菌感染率逐渐下降。然而，成人人群的感染率仍然相对较高，因此需要继续及时诊断幽门螺杆菌并随后进行根除治疗，以降低相关疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Terapevticheskii Arkhiv 医学-医学：内科

CiteScore

1.40

自引率

33.30%

发文量

171

审稿时长

3-8 weeks

期刊介绍： Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.