Posterior parasagittal meningiomas display aggressive features independent of size: a multicenter analysis.

IF 3.2 2区 医学 Q2 CLINICAL NEUROLOGY
Said Koçyiğit, Miguel Millares Chavez, Ömer Orhun, Joseph O'Brien, Arda Inan, A Harun Yaşar, Alp Dinçer, Jennifer Moliterno, Murat Günel, M Necmettin Pamir, Koray Özduman, Ayça Erşen-Danyeli
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Abstract

Purpose: While meningioma size is known to correlate with higher histological grade, tumor behavior can vary by anatomical location, suggesting that some meningiomas may exhibit aggressive features early and independent of size. We hypothesized that posterior parasagittal meningiomas possess unique growth characteristics and tested this hypothesis using a retrospective analysis of two independent cohorts.

Methods: Cohort-A (n = 316) included 123 WHO-grade 2 (GR2) and 193 age and location matched WHO-grade 1 (GR1) meningiomas. Twelve radiological features as well as the histological subtypes, histological grading features and 1p status was evaluated. A volume index (Vi), defined as the GR2/GR1 tumor volume ratio, was calculated across different anatomical locations. Findings were validated in Cohort-B (n = 477), which also included NF2-driven and non-NF2-driven molecular subsets.

Results: Tumor volume correlated strongly with GR2 status (p = 3.5 × 10- 6) and histopathological markers of major grading criteria including mitotic count (p < 0.001), brain invasion (p < 0.05), and minor grading criteria including hypercellularity (p < 0.001), necrosis (p < 0.001) along with increased Ki67 index (p < 0.01). Anatomically, the non-skull base posterior midline (NSB-POST-M) meningiomas had the lowest Vi in both cohorts and the NF2-driven subset indicating that these tumors exhibit aggressive features even at smaller sizes. The NSB-POST-M location had the highest proportion of GR2 cases, mean Ki67 index, and incidence of chromosome 1p loss.

Conclusions: While larger meningiomas are generally more aggressive, posterior parasagittal meningiomas display aggressive biology regardless of size. These findings suggest that anatomical location should be incorporated into risk stratification and management decisions.

后矢状旁脑膜瘤显示侵袭性特征,与大小无关:一项多中心分析。
目的:虽然脑膜瘤的大小与较高的组织学分级相关,但肿瘤的行为可能因解剖位置而异,这表明一些脑膜瘤可能在早期表现出侵袭性特征,且与大小无关。我们假设后矢状旁脑膜瘤具有独特的生长特征,并通过对两个独立队列的回顾性分析来验证这一假设。方法:a队列(n = 316)包括123例who 2级(GR2)脑膜瘤和193例年龄和位置匹配的who 1级(GR1)脑膜瘤。评估12个影像学特征以及组织学亚型、组织学分级特征和1p状态。计算不同解剖位置的体积指数(Vi),定义为GR2/GR1肿瘤体积比。研究结果在队列b (n = 477)中得到验证,其中还包括nf2驱动和非nf2驱动的分子亚群。结果:肿瘤体积与GR2状态(p = 3.5 × 10- 6)和主要分级标准的组织病理学标志物(包括有丝分裂计数)密切相关(在两个队列和nf2驱动的亚组中均为p i),表明这些肿瘤即使在较小的尺寸上也表现出侵袭性特征。NSB-POST-M位点GR2病例比例最高,平均Ki67指数最高,染色体1p丢失发生率最高。结论:虽然较大的脑膜瘤通常更具侵袭性,但无论大小大小,后矢状旁脑膜瘤均表现出侵袭性。这些发现表明,解剖位置应纳入风险分层和管理决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Neuro-Oncology
Journal of Neuro-Oncology 医学-临床神经学
CiteScore
6.60
自引率
7.70%
发文量
277
审稿时长
3.3 months
期刊介绍: The Journal of Neuro-Oncology is a multi-disciplinary journal encompassing basic, applied, and clinical investigations in all research areas as they relate to cancer and the central nervous system. It provides a single forum for communication among neurologists, neurosurgeons, radiotherapists, medical oncologists, neuropathologists, neurodiagnosticians, and laboratory-based oncologists conducting relevant research. The Journal of Neuro-Oncology does not seek to isolate the field, but rather to focus the efforts of many disciplines in one publication through a format which pulls together these diverse interests. More than any other field of oncology, cancer of the central nervous system requires multi-disciplinary approaches. To alleviate having to scan dozens of journals of cell biology, pathology, laboratory and clinical endeavours, JNO is a periodical in which current, high-quality, relevant research in all aspects of neuro-oncology may be found.
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