A Head-to-Head Comparison Between [18F]Fluorodeoxyglucose ([18F]FDG) Positron Emission Tomography/Computed Tomography (PET/CT) and 99mTechnetium-Hexamethylpropylene Amine Oxime (HMPAO)-Labeled Leukocyte Scintigraphy in a Case Series of Patients with Suspected Vascular Prosthesis Infection: To Trust Is Good, but to Check Is Better.

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Marina Scarpuzza, Alice Ambrogio, Andrea Leo, Lorenzo Roberto Suardi, Michele Marconi, Marco Falcone, Raffaella Berchiolli, Elena Lazzeri
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引用次数: 0

Abstract

Background: Prosthetic vascular graft infection (PVGI) is a serious complication associated with vascular prostheses. Nuclear medicine techniques, including [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and 99mtechnetium-hexamethylpropylene amine oxime (HMPAO)-labeled leukocyte (WBC) scintigraphy, are part of the MAGIC diagnostic criteria for PVGI. Methods: In this retrospective study, we analyzed eight patients with suspected PVGI who underwent both [18F]FDG PET/CT and WBC scintigraphy within an average of 8 days. Results: Of all eight patients (median age 69 years), three showed concordant positive results with both PET/CT and WBC, and their final diagnosis confirmed the presence of infection; five showed discordant results: in all five of these patients, PET/CT showed false-positive findings, whereas WBC correctly identified five true-negative cases. Conclusions: [18F]FDG PET/CT is highly sensitive but prone to false positives. WBC scintigraphy, combined with SPECT/CT, particularly in the evaluation of the treatment response, showed greater specificity, and it may warrant consideration as a MAGIC major diagnostic criterion for PVGI.

[18F]氟脱氧葡萄糖([18F]FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)与99m锝-六甲基丙烯胺肟(HMPAO)标记白细胞显像在疑似血管假体感染病例系列中的头部比较:信任是好的,但检查更好。
背景:假体血管移植感染(PVGI)是与血管修复术相关的严重并发症。核医学技术,包括[18F]氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(PET/CT)和99mtechum -六甲基丙烯胺肟(HMPAO)标记白细胞(WBC)闪烁成像,是PVGI的MAGIC诊断标准的一部分。方法:在这项回顾性研究中,我们分析了8例疑似PVGI的患者,他们在平均8天内接受了[18F]FDG PET/CT和WBC扫描。结果:所有8例患者(中位年龄69岁)中,3例PET/CT和WBC均显示一致阳性结果,最终诊断证实存在感染;5例显示不一致的结果:在所有5例患者中,PET/CT显示假阳性结果,而WBC正确识别了5例真阴性病例。结论:[18F]FDG PET/CT具有高灵敏度,但易出现假阳性。白细胞显像结合SPECT/CT,特别是在评估治疗反应时,显示出更大的特异性,可能值得考虑将其作为PVGI的主要诊断标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Medicine
Journal of Clinical Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
5.70
自引率
7.70%
发文量
6468
审稿时长
16.32 days
期刊介绍: Journal of Clinical Medicine (ISSN 2077-0383), is an international scientific open access journal, providing a platform for advances in health care/clinical practices, the study of direct observation of patients and general medical research. This multi-disciplinary journal is aimed at a wide audience of medical researchers and healthcare professionals. Unique features of this journal: manuscripts regarding original research and ideas will be particularly welcomed.JCM also accepts reviews, communications, and short notes. There is no limit to publication length: our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.
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