Next-Generation Drug Delivery for Neurotherapeutics: The Promise of Stimuli-Triggered Nanocarriers.

IF 3.9 3区工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedicines Pub Date : 2025-06-13 DOI:10.3390/biomedicines13061464

Radka Boyuklieva, Nikolay Zahariev, Plamen Simeonov, Dimitar Penkov, Plamen Katsarov

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Abstract

Nanotherapeutics have emerged as novel unparalleled drug delivery systems (DDSs) for the treatment of neurodegenerative disorders. By applying different technological approaches, nanoparticles can be engineered to possess different functionalities. In recent years, the developed, stimuli-responsive nanocarriers stand out as novel complex DDSs ensuring selective and specific drug delivery in response to different endogenous and exogenous stimuli. Due to the multifaceted pathophysiology of the nervous system, a major challenge in modern neuropharmacology is the development of effective therapies ensuring high efficacy and low toxicity. Functionalization of the nanocarriers to react to specific microenvironmental changes in the nervous system tissues or external stimulations significantly enhances the efficacy of drug delivery. This review discusses the microenvironmental characteristics of some common neurological diseases in-depth and provides a comprehensive overview on the progress of the development of exogenous and endogenous stimuli-sensitive nanocarriers for the treatment of Alzheimer's and Parkinson's disease.

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神经治疗的下一代药物递送：刺激触发纳米载体的前景。

纳米疗法已经成为治疗神经退行性疾病的一种新的、无与伦比的药物传递系统（dds）。通过应用不同的技术方法，纳米颗粒可以被设计成具有不同的功能。近年来，开发的刺激反应性纳米载体作为新型复杂dds脱颖而出，确保药物在不同内源性和外源性刺激下的选择性和特异性递送。由于神经系统的病理生理是多方面的，现代神经药理学的一个主要挑战是开发有效的治疗方法，确保高效和低毒性。功能化纳米载体对神经系统组织中特定微环境变化或外部刺激的反应显著提高了药物递送的功效。本文深入讨论了一些常见神经系统疾病的微环境特征，并对外源性和内源性刺激敏感纳米载体治疗阿尔茨海默病和帕金森病的研究进展进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

5.20

自引率

8.50%

发文量

2823

审稿时长

8 weeks

期刊介绍： Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.