General Modular and Convergent Approach to Diversely Functionalized Allylic Systems.

Abstract

Synthesis of allylic functionalized motifs forging C-O, C-C, and C-S bonds has been achieved via visible-light-induced palladium catalysis. Simple alkenes, readily available 1,1-dielectrophiles, and commercially available nucleophiles are directly coupled in a sequential manner to construct a diverse array of medicinally relevant complex molecules. Unlike the classical Tsuji-Trost reaction, this protocol eliminates the need for prefunctionalized starting materials, offering a much more general and modular approach with options for stereoselective reactions. Additionally, inherent synthetic challenges associated with oxygen-, carbon-, and sulfur-based nucleophiles are addressed, thus establishing a versatile toolkit for accessing allylic ethers, esters, sulfones, and alkylated motifs.