Current Update on DWI-MRI and Its Radiomics in Liver Fibrosis-A Review of the Literature.

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Tomography Pub Date : 2025-05-30 DOI:10.3390/tomography11060063

Ali S Alyami

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引用次数: 0

Abstract

Introduction: Diffusion-weighted imaging (DWI) is a non-invasive technique for acquiring liver pathology data and characterizing liver lesions. This modality shows promise for applications in the initial diagnosis and monitoring of liver diseases, providing valuable insights for clinical assessment and treatment strategies. Intravoxel incoherent motion (IVIM), diffusion kurtosis imaging (DKI), and diffusion tensor imaging (DTI) are advanced forms of DWI. These techniques have proven effective for assessing liver lesions, including liver tumors and fibrosis. However, the results can be inconsistent. Thus, it is essential to summarize the current applications of these methods in liver fibrosis, identify existing limitations, and suggest future directions for development.

Methods: This review assessed studies concerning liver DWI and its applications published in the PubMed database over the last nine years. It presents these techniques' fundamental principles and key factors before discussing their application in liver fibrosis.

Results and conclusions: It has been observed that advanced DWI sequences remain unreliable in ensuring the robustness and reproducibility of measurements when assessing liver fibrosis grades, due to inconsistent results and significant overlap among these techniques across different stages of fibrotic conditions.

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肝纤维化DWI-MRI及其放射组学研究进展——文献综述。

简介：弥散加权成像（DWI）是一种获取肝脏病理数据和表征肝脏病变的非侵入性技术。这种模式有望应用于肝脏疾病的初步诊断和监测，为临床评估和治疗策略提供有价值的见解。体素内非相干运动（IVIM）、扩散峰态成像（DKI）和扩散张量成像（DTI）是DWI的高级形式。这些技术已被证明是有效的评估肝脏病变，包括肝肿瘤和肝纤维化。然而，结果可能不一致。因此，有必要总结这些方法在肝纤维化中的应用现状，确定存在的局限性，并提出未来的发展方向。方法：本综述评估了近9年来PubMed数据库中发表的有关肝脏DWI及其应用的研究。介绍了这些技术的基本原理和关键因素，并讨论了它们在肝纤维化中的应用。结果和结论：据观察，在评估肝纤维化等级时，由于结果不一致以及这些技术在不同纤维化阶段之间的显著重叠，先进的DWI序列在确保测量结果的稳健性和可重复性方面仍然不可靠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.