Predictors of Major Adverse Cardiovascular Events in Stable Patients After ST Elevation Myocardial Infarction.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
Lidija Savic, Damjan Simic, Ratko Lasica, Gordana Krljanac, Sanja Stankovic, Igor Mrdovic, Milika Asanin
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Abstract

Background/aim: The aim of this study was to determine predictors of major adverse cardiovascular events, including MACE (mortality, non-fatal recurrent infarction, non-fatal stroke, and target vessel revascularization-TVR) in stable post-STEMI patients.

Method: We analyzed STEMI patients without cardiogenic shock at admission included in our STEMI Register. The patients were treated with primary PCI. The follow-up period was eight years.

Results: From 1 December 2006 to 31 December 2016, a total of 3079 patients were included in the Register. In the first year, MACE was registered in 348 (11.3%) patients. The remaining patients were considered stable. They were included in further analysis. At eight years, the rates were as follows: MACE 3.9%, non-fatal recurrent infarction 2.1%, TVR 1.8%, non-fatal stroke 0.5%, and mortality 2.1%. Predictors for 8-year MACE were age >60 years (60-69 vs. <60 years HR 1.65; 70-79 vs. <60 years HR 1.82; ≥80 vs. <60 years HR 3.16), EF < 50% (EF 40-49% HR 2.38; EF < 40% HR 2.32), diabetes mellitus (HR 1.49), and 3-vessel coronary artery disease (HR 1.44).

Conclusions: Four predictors identified stable post-STEMI patients who remained at a higher risk for the occurrence of MACE. Stable post-STEMI patients with one or more of these risk factors may require more aggressive secondary prevention measures or a personalized approach to improve their prognosis.

ST段抬高型心肌梗死后稳定患者主要不良心血管事件的预测因素
背景/目的:本研究的目的是确定稳定stemi后患者主要不良心血管事件的预测因素,包括MACE(死亡率、非致死性复发性梗死、非致死性卒中和靶血管重建术- tvr)。方法:我们分析纳入STEMI登记的入院时无心源性休克的STEMI患者。患者均行首次PCI治疗。随访期为8年。结果:2006年12月1日至2016年12月31日,共纳入3079例患者。第一年,348例(11.3%)患者登记了MACE。其余患者情况稳定。它们被纳入进一步的分析。8年时,MACE为3.9%,非致死性复发性梗死2.1%,TVR为1.8%,非致死性卒中0.5%,死亡率2.1%。8年MACE的预测因子为60 ~ 60岁(60 ~ 69岁vs.结论:4个预测因子确定了稳定的stemi后患者发生MACE的风险仍然较高。具有上述一种或多种危险因素的稳定stemi后患者可能需要更积极的二级预防措施或个性化方法来改善其预后。
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来源期刊
Clinics and Practice
Clinics and Practice MEDICINE, GENERAL & INTERNAL-
CiteScore
2.60
自引率
4.30%
发文量
91
审稿时长
10 weeks
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