HLA DRB1* Allele Lupus Erythematosus, Rheumatoid Arthritis, and other Autoimmune Disorders with Skin Involvement.

Q4 Medicine

Mediterranean Journal of Rheumatology Pub Date : 2025-03-30 eCollection Date: 2025-03-01 DOI:10.31138/mjr.111024.oad

Eleni Klimi

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Abstract

Objective: A narrative short review has been made aiming to identify the most important immune disorders associated with the HLA DRB1*allele.

Material and methods: Data have been taken from PubMed, and 36 articles have been retrieved.

Results: It has been found that DRB1*16:02 is associated with autoimmune diseases with production of autoantibodies, mainly systemic lupus erythematosus and myasthenia gravis. DRB1*04 is associated with lupus erythematosus, bullous pemphigoid, and pemphigus vulgaris. DRB1*is also associated with dermatitis herpetiformis, alopecia areata, acute generalised exanthematous pustulosis, and systemic sclerosis. No association of DRB1 has been found either with psoriasis or with psoriatic arthritis, while the association of Cw6 and DRB1*07 confers less severe joint damage in patients with psoriatic arthritis.

Conclusion: DRB1* is associated with lupus erythematosus rheumatoid arthritis and with most immune disorders with skin involvement.

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HLA DRB1*等位基因红斑狼疮、类风湿性关节炎和其他皮肤受累的自身免疫性疾病。

目的：对与HLA DRB1*等位基因相关的最重要的免疫疾病进行综述。材料和方法：数据来源于PubMed，共检索到36篇文章。结果：研究发现DRB1*16:02与自身免疫性疾病相关，主要是系统性红斑狼疮和重症肌无力。DRB1*04与红斑狼疮、大疱性类天疱疮和寻常性天疱疮有关。DRB1*也与疱疹样皮炎、斑秃、急性全身性发疹性脓疱病和系统性硬化症有关。没有发现DRB1与银屑病或银屑病关节炎的关联，而Cw6和DRB1*07的关联使银屑病关节炎患者的关节损伤较轻。结论：DRB1*与红斑狼疮、类风湿关节炎和大多数皮肤受累的免疫疾病有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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