Cobalt-Catalyzed C–H Annulation of Aryl Sulfonamides and Benzamides with CaC2 as the Acetylene Source

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-25 DOI:10.1021/acs.orglett.5c01981

Aleksandrs Cizikovs, and , Liene Grigorjeva*,

引用次数: 0

Abstract

We have developed a cobalt-catalyzed, aminoquinoline-directed C–H/N–H annulation reaction of benzamides and aryl sulfonamides, enabling access to 3,4-unsubstituted isoquinolinone and 3,4-unsubstituted benzothiazine dioxide derivatives. This method employs calcium carbide as an inexpensive, easy-to-handle, and solid acetylene source. The reaction conditions showed a broad functional group tolerance, which allowed the synthesis of various C–H/C–N annulation products in yields of up to 99%.

Abstract Image

查看原文本刊更多论文

以CaC2为乙炔源，钴催化芳基磺酰胺和苯酰胺的碳氢环化反应。

我们已经开发了一种钴催化的，氨基喹啉导向的苯酰胺和芳基磺胺的C-H/N-H环化反应，可以获得3,4-未取代的异喹啉酮和3,4-未取代的苯并噻嗪二氧化衍生物。该方法采用电石作为廉价、易于处理的固体乙炔源。该反应条件具有较宽的官能团耐受性，可合成各种C-H/C-N环状产物，收率高达99%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.