VaxGO: an interactive web tool for systems vaccinology data analysis.

IF 2.4 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY

Bioinformatics advances Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI:10.1093/bioadv/vbaf101

Wasim Aluísio Prates-Syed, Aline Aparecida Lima, Nelson Cortes, Evelyn Carvalho, Jaqueline Dinis Queiroz Silva, Bárbara Hamaguchi, Ricardo Durães-Carvalho, Otávio Cabral-Marques, Thomas Hagan, José E Krieger, Gustavo Cabral-Miranda

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引用次数: 0

Abstract

Motivation: RNA sequencing is crucial for investigating transcriptional patterns in immunology and vaccine research. However, the analysis of RNA sequencing data often requires programming skills, which can limit accessibility for researchers lacking such expertise.

Results: We present VaxGO, an intuitive web-based tool designed to facilitate the analysis of differentially expressed genes in the context of immune processes and cells during vaccination. This tool integrates data from Gene Ontology, CellMarker 2.0, the MSigDB Vax collection, and other key studies, including transcriptional atlases of vaccines against COVID-19 and other diseases. VaxGO is an interactive, web-based tool, offering a user-friendly platform for exploring immune responses and vaccine efficacy without programming expertise.

Availability and implementation: The VaxGO tool is available at https://github.com/wapsyed/VaxGO.

查看原文本刊更多论文

VaxGO：用于系统疫苗学数据分析的交互式网络工具。

动机：RNA测序对免疫学和疫苗研究中的转录模式研究至关重要。然而，RNA测序数据的分析通常需要编程技能，这可能会限制缺乏这种专业知识的研究人员的可访问性。结果：我们提出了VaxGO，一个直观的基于网络的工具，旨在促进免疫过程和接种期间细胞中差异表达基因的分析。该工具整合了来自Gene Ontology、CellMarker 2.0、MSigDB Vax收集和其他关键研究的数据，包括针对COVID-19和其他疾病的疫苗转录图谱。VaxGO是一个交互式的基于网络的工具，提供了一个用户友好的平台，可以在没有编程专业知识的情况下探索免疫反应和疫苗功效。可用性和实现：VaxGO工具可从https://github.com/wapsyed/VaxGO获得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioinformatics advances

CiteScore

1.60

自引率

0.00%

发文量