Immune biomarkers as early indicators of renal damage in type 1 diabetic children: A step toward translational medicine.

IF 4.2 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Jian-Wen Fan, Su-Yi Xu, Jun Wu, Yong-Wei Yu
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引用次数: 0

Abstract

An article recently published in the World Journal of Diabetes, provides valuable insights into using immune biomarkers to identify renal damage in pediatric patients with newly diagnosed type 1 diabetes (T1D). Although these findings are promising, clinical translation of these immune markers into routine diagnostics and preventive care remains challenging. In this letter, we propose building on the authors' work by exploring the integration of immune biomarkers into a more comprehensive dynamic risk stratification model for early renal injury. Combining immune system indicators with metabolic and genetic factors could enhance the predictive accuracy and support more personalized interventions. Longitudinal studies are needed to evaluate temporal changes in immune biomarkers and their association with long-term renal outcomes in children with T1Ds. Immunomodulatory therapies targeting early immune dysfunction can prevent or slow the progression of diabetic nephropathy. By incorporating these aspects, we hope to translate immune biomarkers from research into practical clinical tools, ultimately improving patient outcomes and reducing the burden of kidney-related complications in pediatric diabetes.

免疫生物标志物作为1型糖尿病儿童肾脏损害的早期指标:向转化医学迈出的一步。
最近发表在《世界糖尿病杂志》(World Journal of Diabetes)上的一篇文章为利用免疫生物标志物识别新诊断的1型糖尿病(T1D)儿科患者的肾脏损害提供了有价值的见解。尽管这些发现很有希望,但将这些免疫标记物转化为常规诊断和预防保健仍然具有挑战性。在这封信中,我们建议在作者工作的基础上,探索将免疫生物标志物整合到早期肾损伤的更全面的动态风险分层模型中。将免疫系统指标与代谢和遗传因素结合起来可以提高预测的准确性,支持更个性化的干预措施。需要进行纵向研究来评估t1d儿童免疫生物标志物的时间变化及其与长期肾脏预后的关系。针对早期免疫功能障碍的免疫调节治疗可以预防或减缓糖尿病肾病的进展。通过整合这些方面,我们希望将研究中的免疫生物标志物转化为实用的临床工具,最终改善患者的预后,减轻儿童糖尿病肾脏相关并发症的负担。
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来源期刊
World Journal of Diabetes
World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
自引率
2.40%
发文量
909
期刊介绍: The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
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