Vitamin D deficiency is associated with apolipoprotein A1 levels in patients with young-onset type 2 diabetes mellitus.

IF 4.2 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Ye Hu, Li-Na Shao, Jia Zheng, Xin-Miao Zhang, Ying-Xiang Song, Yu-Bo Xing
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Abstract

Background: Young-onset type 2 diabetes mellitus (T2DM) is associated with adverse health outcomes and increased mortality. Vitamin D (VitD) deficiency is likewise linked to various adverse health outcomes and is significantly associated with lipid metabolism in patients with T2DM. However, little is known regarding the mechanisms of interaction between VitD and apolipoprotein A1 (apoA1) in young-onset T2DM.

Aim: To evaluate the relationship between VitD and apoA1 levels in patients with young-onset T2DM.

Methods: This cross-sectional study was conducted at Zhejiang Provincial People's Hospital between January 2019 and December 2023. A total of 642 patients with T2DM who aged 18-40 years were included and matched with 642 individuals without diabetes (controls) based on age and sex. No specific intervention was applied, and data were collected from medical records and laboratory tests. The relationship between VitD and apoA1 levels was examined using Spearman's correlation and logistic regression models.

Results: We found that VitD levels were significantly lower in patients with T2DM compared to controls (15.9 ng/mL vs 17.4 ng/mL, P < 0.001), with a notable positive correlation between VitD deficiency and reduced apoA1 levels. Multifactor logistic regression analysis identified that severe VitD deficiency was an independent risk factor for apoA1 in young-onset T2DM patients (odds ratio = 3.43, 95% confidence interval: 1.16-10.20, β = 1.23, P = 0.026).

Conclusion: Our findings reveal an association between VitD and apoA1 in young-onset T2DM, suggesting that VitD may play a crucial role in metabolic regulation and cardiovascular risk management.

年轻发病的2型糖尿病患者维生素D缺乏与载脂蛋白A1水平相关。
背景:年轻发病的2型糖尿病(T2DM)与不良健康结局和死亡率增加相关。维生素D (VitD)缺乏同样与各种不良健康结果有关,并与T2DM患者的脂质代谢显著相关。然而,关于年轻发病T2DM中VitD与载脂蛋白A1 (apoA1)相互作用的机制知之甚少。目的:探讨年轻发病T2DM患者VitD与apoA1水平的关系。方法:本横断面研究于2019年1月至2023年12月在浙江省人民医院进行。共纳入642例年龄在18-40岁的T2DM患者,并根据年龄和性别与642例非糖尿病患者(对照组)相匹配。没有采用具体的干预措施,数据收集自医疗记录和实验室检测。采用Spearman相关和logistic回归模型检验VitD与apoA1水平的关系。结果:我们发现T2DM患者的VitD水平明显低于对照组(15.9 ng/mL vs 17.4 ng/mL, P < 0.001), VitD缺乏与apoA1水平降低之间存在显著正相关。多因素logistic回归分析发现,严重维生素d缺乏是年轻发病T2DM患者apoA1的独立危险因素(优势比= 3.43,95%可信区间:1.16-10.20,β = 1.23, P = 0.026)。结论:我们的研究结果揭示了年轻发病T2DM患者维生素d与apoA1之间的关联,表明维生素d可能在代谢调节和心血管风险管理中发挥重要作用。
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来源期刊
World Journal of Diabetes
World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
自引率
2.40%
发文量
909
期刊介绍: The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
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