BRAIN-Diabetes: a randomised trial to test the feasibility of an adapted FINGER multidomain intervention in adults with type 2 diabetes living in rural border regions of Ireland.

IF 3.7 2区 社会学 Q1 GERONTOLOGY
Claire T McEvoy, Geraldine McCarthy, Rebecca F Townsend, Catherine Dolan, Joanne Regan-Moriarty, Christopher Cardwell, Bernadette McGuinness, Seán P Kennelly, Jim Kelly, Catherine McHugh, Frank Kee, John Bartlett, Caroline Bradshaw, Orla Reynolds, Valerie Mortland, Christina O'Neill, Ingrid McLoughlin, Noel McCaffrey, Margaret Heffernan, Cabrini Nolan, Peter A Passmore
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引用次数: 0

Abstract

Background: The Border Region Area lifestyle INtervention for healthy cognitive ageing in Diabetes' (BRAIN-Diabetes) trial aimed to test the feasibility of an adapted version of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain intervention in cognitively healthy adults at risk of dementia living in border regions of Ireland.

Methods: BRAIN-Diabetes was a 6-month randomised controlled pilot trial involving adults living in rural border regions who were ≥ 50 years old, without existing dementia but had a diagnosis of type 2 diabetes and access to a computer. Individuals were randomised to either the multidomain intervention or the standard care control group. The intervention included diet counselling, physical exercise and computerised cognitive training which were delivered remotely and cardiometabolic risk monitoring which was delivered in person. The primary outcomes assessed feasibility of recruitment/retention and adherence to the intervention. Other outcomes explored intervention effects on cognitive, metabolic and health-related quality of life.

Results: In total, 156 individuals were assessed for eligibility, and 79 (51%) were recruited (mean age 61.6 ± 6.9 (range 60-75) years; 68% male). After 6 months, retention was 81% (72% in intervention versus 90% control). Adherence rate was high with most participants attending > 50% of the scheduled intervention sessions. There was greater improvement in diet quality (p < 0.001), daily step count (p = 0.04), triglyceride levels (p = 0.02) and health-related quality of life (p < 0.05) in the intervention group compared to control. There were no observed intervention effects on cognitive performance over 6 months.

Conclusions: The BRAIN-Diabetes pilot trial demonstrated that an adapted FINGER model was feasible to deliver and efficacious in supporting lifestyle behavioural changes among a unique at-risk rural population. There were also indicative benefits for metabolic health and health-related quality of life over a short time frame. Trial registration ClinicalTrials.gov (registration ref: NCT05304975 accepted 31st March 2022).

脑-糖尿病:一项随机试验,旨在测试适应FINGER多域干预在爱尔兰农村边境地区2型糖尿病成人患者中的可行性。
背景:“边境地区生活方式干预糖尿病健康认知衰老”(BRAIN-Diabetes)试验旨在测试芬兰老年干预研究的改编版本,以预防认知障碍和残疾(FINGER)多领域干预生活在爱尔兰边境地区有痴呆风险的认知健康成年人的可行性。方法:BRAIN-Diabetes是一项为期6个月的随机对照试验,研究对象为生活在农村边境地区的成年人,年龄≥50岁,无痴呆,但诊断为2型糖尿病,可以使用计算机。个体被随机分配到多领域干预组或标准护理对照组。干预包括远程提供的饮食咨询、体育锻炼和计算机化认知训练,以及亲自提供的心脏代谢风险监测。主要结果评估了招募/保留和坚持干预的可行性。其他结果探讨了干预对认知、代谢和健康相关生活质量的影响。结果:共有156人被评估为合格,79人(51%)被招募(平均年龄61.6±6.9(范围60-75)岁;68%的男性)。6个月后,保留率为81%(干预组为72%,对照组为90%)。依从率很高,大多数参与者参加了50%的预定干预会议。结论:脑-糖尿病试点试验表明,适应的FINGER模型在支持独特的高危农村人群的生活方式行为改变方面是可行的和有效的。在短时间内,代谢健康和与健康相关的生活质量也有指示性的益处。临床试验注册:ClinicalTrials.gov(注册编号:NCT05304975,接受于2022年3月31日)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.50
自引率
7.90%
发文量
72
期刊介绍: The European Journal of Ageing: Social, Behavioural and Health Perspectives is an interdisciplinary journal devoted to the understanding of ageing in European societies and the world over. EJA publishes original articles on the social, behavioral and population health aspects of ageing and encourages an integrated approach between these aspects. Emphasis is put on publishing empirical research (including meta-analyses), but conceptual papers (including narrative reviews) and methodological contributions will also be considered. EJA welcomes expert opinions on critical issues in ageing. By stimulating communication between researchers and those using research findings, it aims to contribute to the formulation of better policies and the development of better practice in serving older adults. To further specify, with the term ''social'' is meant the full scope of social science of ageing related research from the micro to the macro level of analysis. With the term ''behavioural'' the full scope of psychological ageing research including life span approaches based on a range of age groups from young to old is envisaged. The term ''population health-related'' denotes social-epidemiological and public health oriented research including research on functional health in the widest possible sense.
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