Transcutaneous Cervical Vagus Nerve Stimulation Modulates Prefrontal Cortex Activity During Opioid Withdrawal in Individuals With Opioid Use Disorder.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Neuromodulation Pub Date : 2025-06-23 DOI:10.1016/j.neurom.2025.04.012

Farhan N Rahman, Afra Nawar, Jonathon A Nye, Jaiyoun Choi, Tamara P Lambert, Madeline Robinson, Asim H Gazi, Vikram Abbaraju, Nikolina Tomic, Anna B Harrison, Nora Jaquemet, Kellen Mermin-Bunnell, Hewitt Mesfin, Trinity A Gray, Justine W Welsh, Kelly E Dunn, Marom Bikson, Viola Vaccarino, Amit J Shah, Omer T Inan, James Douglas Bremner

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引用次数: 0

Abstract

Background: Opioid use disorder (OUD) is associated with considerable morbidity and mortality with limited treatment approaches. Understanding brain mechanisms in response to treatment could be useful in guiding future developments in treatment approaches.

Objective: The purpose of this study was to assess the effects of transcutaneous cervical vagus nerve stimulation (tcVNS) on brain response to opioid use cues in patients with OUD in opioid withdrawal.

Materials and methods: Patients with OUD who were in the early stage of recovery and/or on medication underwent brain imaging with positron emission tomography and radiolabeled water in conjunction with stimulation with active tcVNS or sham devices and exposure to opioid-use-related cues.

Results: tcVNS caused a relative increase in function in the anterior cingulate, dorsal anterior cingulate, and left inferior frontal gyrus during exposure to opioid cues. There also was a pattern of increased activation in the ventral striatum and orbitofrontal cortex.

Conclusion: tcVNS modulates brain areas implicated in opioid addiction, suggesting a useful role as an adjunctive therapy for OUD.

Clinical trial registration: The Clinicaltrials.gov registration number for the study is NCT04556552.

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经皮颈迷走神经刺激在阿片类药物使用障碍患者戒断阿片类药物期间调节前额叶皮层活动。

背景：阿片类药物使用障碍（OUD）与相当高的发病率和死亡率相关，治疗方法有限。了解大脑机制对治疗的反应可能有助于指导未来治疗方法的发展。目的：本研究的目的是评估经皮颈迷走神经刺激（tcVNS）对阿片类药物戒断的OUD患者对阿片类药物使用提示的脑反应的影响。材料和方法：处于恢复早期和/或正在接受药物治疗的OUD患者采用正电子发射断层扫描和放射性标记水进行脑成像，同时使用活性tcVNS或假装置进行刺激，并暴露于阿片类药物使用相关提示。结果：在暴露于阿片线索时，tcVNS引起了前扣带、前扣带背侧和左额下回功能的相对增加。在腹侧纹状体和眶额皮层也有一种增加的激活模式。结论：tcVNS可调节与阿片成瘾有关的脑区，提示其可作为OUD的辅助治疗。临床试验注册：该研究的Clinicaltrials.gov注册号为NCT04556552。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuromodulation 医学-临床神经学

CiteScore

6.40

自引率

3.60%

发文量

978

审稿时长

54 days

期刊介绍： Neuromodulation: Technology at the Neural Interface is the preeminent journal in the area of neuromodulation, providing our readership with the state of the art clinical, translational, and basic science research in the field. For clinicians, engineers, scientists and members of the biotechnology industry alike, Neuromodulation provides timely and rigorously peer-reviewed articles on the technology, science, and clinical application of devices that interface with the nervous system to treat disease and improve function.