Determination of Risk Factors Influencing Psoriatic Arthritis Screening and Evaluation Questionnaire Scores in Palmoplantar Pustulosis: Post Hoc Analysis of EPPPIK Study.

IF 3.5 3区医学 Q1 DERMATOLOGY

Dermatology and Therapy Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI:10.1007/s13555-025-01460-9

Byung Soo Kim, Seong Jin Jo, Dong Hyun Kim, Hee Joo Kim, Chul Hwan Bang, Bong Seok Shin, Joo-Heung Lee, Ju Hee Lee, Sung Eun Chang, Kyung-Eun Jung, Youngdoe Kim, Jihye An, Sang Woong Youn, Chul Jong Park

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引用次数: 0

Abstract

Introduction: Palmoplantar pustulosis (PPP) is a chronic inflammatory skin condition characterized by pustules on the palms and soles. Patients with PPP may be at an increased risk of developing psoriatic arthritis (PsA). The Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire is a tool designed to screen for PsA in at-risk populations. The objective of this study was to identify potential risk factors influencing PASE scores in patients with PPP.

Methods: The EPPPIK study was a cross-sectional, multicenter, noninterventional study conducted at 20 sites in Korea, in which patients (≥ 19 years of age) with a confirmed PPP diagnosis were reviewed. In a post hoc analysis of EPPPIK data, PASE outcomes were evaluated for two groups of patients with PPP stratified on the basis of a cutoff score of 37 points.

Results: In total, 375 patients with PPP (mean age, 51.3 years; 38.9% male) were included. At enrollment, 175 (46.7%) patients had a PASE score ≥ 37, and 200 (53.3%) patients had a PASE score < 37. Significant differences between the groups were demonstrated for sex, age of menarche, presence of arthritis or psoriatic arthropathy, Physician's Global Assessment score, Palmo-Plantar Pustulosis Area and Severity Index (PPPASI) score, and hand PPPASI score (p ≤ 0.05). Quality-of-life (QoL) measurements and patient-reported outcomes were significantly worse in patients with PASE ≥ 37 (p ≤ 0.05). Multivariable linear regression analysis revealed that a PASE score ≥ 37 was positively associated with female sex (β = 7.19; p < 0.001) and high hand PPPASI score (β = 0.22; p = 0.0243).

Conclusions: In patients with PPP, PASE score ≥ 37 correlated with increased presence of any arthritis or psoriatic arthropathy, more severe PPP, worse QoL outcomes, female sex, and higher hand PPPASI scores. Therefore, PASE may serve as a useful tool for initial screening and appropriate treatment selection, management, and ongoing monitoring of patients with PPP.

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影响掌跖脓疱病银屑病关节炎筛查和评估问卷得分的危险因素的确定：EPPPIK研究的事后分析。

掌跖脓疱病（PPP）是一种慢性炎症性皮肤病，其特征是手掌和脚底的脓疱。PPP患者患银屑病关节炎（PsA）的风险可能会增加。银屑病关节炎筛查和评估（PASE）问卷是一种用于筛查高危人群PsA的工具。本研究的目的是确定影响PPP患者PASE评分的潜在危险因素。方法：EPPPIK研究是一项横断面、多中心、非介入性研究，在韩国20个地点进行，研究对象是确诊为PPP的患者（≥19岁）。在对EPPPIK数据的事后分析中，根据37分的临界值对两组PPP患者的PASE结果进行了评估。结果：共375例PPP患者(平均年龄51.3岁；38.9%为男性)。在入组时，175例（46.7%）患者PASE评分≥37,200例（53.3%）患者PASE评分。结论：在PPP患者中，PASE评分≥37与关节炎或银屑病关节病的存在增加、PPP更严重、生活质量更差、女性和手部PPPASI评分较高相关。因此，PASE可作为PPP患者的初始筛查和适当治疗选择、管理和持续监测的有用工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology and Therapy Medicine-Dermatology

CiteScore

6.00

自引率

8.80%

发文量

187

审稿时长

6 weeks

期刊介绍： Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.