Associations between MASLD phenotypes and the risk of carotid artery plaque: a cross-sectional study among railway workers.

IF 3.1 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Jia Pan, Honglian Zeng, Yongyan Song, Xiaoli Zhang, Zihang Wang, Lei Tang, Bo Xie, Rong Peng, Yuanyuan Zhou, Beizhong Liu
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引用次数: 0

Abstract

Aims: Current evidence on the association between metabolic dysfunction-associated steatotic liver disease (MASLD) phenotypes to carotid artery plaque (CAP) remains limited. This study aims to investigate both the association and the potential mediating effects of MASLD phenotypes on the risk of CAP.

Methods: In this cross-sectional study, 8644 participants were categorized into five groups based on hepatic steatosis and cardiometabolic criteria: Non-hepatic steatosis, Dysglycemia-MASLD, Overweight-MASLD, Lean-MASLD, and other hepatic steatosis. Multivariable logistic regression analysis was conducted to evaluate the association between MASLD phenotypes and CAP. Mediation analyses were performed to evaluate the mediating effect of dysglycemia and body mass index (BMI) on the relationship between MASLD and CAP.

Results: The Dysglycemia-MASLD group exhibited the highest prevalence of CAP of 26.28%, followed by the Lean-MASLD (18.55%) and Overweight-MASLD (14.39%) groups. After adjusting for covariates, Dysglycemia-MASLD patients had a significantly higher risk of CAP, with an OR of 1.599 (95% CI 1.348, 1.896). Notably, individuals under 45 in the Dysglycemia-MASLD and Lean-MASLD subgroups had more than a two-fold increased risk of CAP compared to the Non-hepatic steatosis group, with ORs of 2.393 (95% CI 1.660, 3.416) and 2.724 (95% CI 1.002, 6.221), respectively. Mediation analysis indicated that dysglycemia and BMI mediated 30.86% and 24.49% of the association of MASLD with CAP.

Conclusion: The risk of developing CAP varies across MASLD phenotypes, with Dysglycemia-MASLD and Lean-MASLD patients exhibiting the highest risk. Therefore, personalized health management strategies are essential for different MASLD phenotypes.

MASLD表型与颈动脉斑块风险之间的关系:铁路工人的横断面研究。
目的:目前关于代谢功能障碍相关脂肪变性肝病(MASLD)表型与颈动脉斑块(CAP)之间关联的证据仍然有限。本研究旨在探讨MASLD表型与cap风险的关联及其潜在的介导作用。方法:在这项横断面研究中,8644名参与者根据肝脂肪变性和心脏代谢标准分为五组:非肝性脂肪变性、血糖异常-MASLD、超重-MASLD、瘦型-MASLD和其他肝脂肪变性。通过多变量logistic回归分析评估MASLD表型与CAP之间的关系。通过中介分析评估血糖异常和体重指数(BMI)对MASLD与CAP之间关系的中介作用。结果:血糖异常-MASLD组CAP患病率最高,为26.28%,其次是瘦-MASLD组(18.55%)和超重-MASLD组(14.39%)。在调整协变量后,血糖异常- masld患者发生CAP的风险明显更高,OR为1.599 (95% CI 1.348, 1.896)。值得注意的是,与非肝性脂肪变性组相比,45岁以下的血糖异常- masld和精益- masld亚组的CAP风险增加了两倍以上,or分别为2.393 (95% CI 1.660, 3.416)和2.724 (95% CI 1.002, 6.221)。中介分析显示,血糖异常和BMI分别介导了MASLD与CAP相关性的30.86%和24.49%。结论:不同的MASLD表型发生CAP的风险不同,血糖异常-MASLD和瘦-MASLD患者发生CAP的风险最高。因此,针对不同的MASLD表型,个性化的健康管理策略至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Diabetologica
Acta Diabetologica 医学-内分泌学与代谢
CiteScore
7.30
自引率
2.60%
发文量
180
审稿时长
2 months
期刊介绍: Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.
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