{"title":"Evaluating the Efficacy and Safety of Kinesiology Tape Wrapping as Adjunct Therapy for Epidermal Growth Factor Receptor–Induced Paronychia","authors":"Ying-Hsiang Wang, Shang-Hung Lin, Yu-Wen Cheng, Yi-Chien Yang, Ting-Jung Hsu","doi":"10.1155/dth/7019466","DOIUrl":null,"url":null,"abstract":"<div>\n <p><b>Background:</b> Current therapies for epidermal growth factor receptor inhibitor (EGFRI)–related paronychia demonstrate effectiveness; however, some patients respond poorly and experience recurrent painful granulation tissue, particularly in weight-bearing areas such as the big toes. Based on promising results from our previous pilot study by Hsu and colleagues, novel kinesiology tape wrapping, which physically shields the inflamed periungual tissue from irritation by the nail plate, has emerged as a potentially effective adjunct therapy.</p>\n <p><b>Objectives:</b> This open-label, randomized-controlled, single-center study was aimed to evaluate the efficacy and safety of kinesiology tape wrapping in cancer patients with EGFRI-related paronychia.</p>\n <p><b>Materials and Methods:</b> Eligible participants were assigned to receive either kinesiology tape wrapping in combination with conventional therapies or conventional therapies alone for 12 weeks. Efficacy outcomes, including the reduction of subjective pain assessed by the numerical rating scale (NRS) and the objective single-digit scoring system for paronychia related to oncologic treatments (single-digit SPOT), as well as adverse events (AEs), were recorded at baseline and at Weeks 1, 2, 4, 8, and 12 postenrollment.</p>\n <p><b>Results:</b> A total of 24 patients were randomized, of which, 22 qualified for analysis. The rate of continuous tape use was 36.3%. At Week 12, pain NRS scores showed no significant differences between groups, while patients treated with continuous or intermittent kinesiology tape wrapping demonstrated notably greater reductions in single-digit SPOT scores compared to those receiving conventional therapy alone (NRS: 3.27 vs. 2.78, <i>p</i> = 0.586; single-digit SPOT: 5.32 vs. 1.52, <i>p</i> = 0.022). No serious AEs were reported.</p>\n <p><b>Conclusion:</b> Kinesiology tape wrapping is an effective and safe adjunct noninvasive therapy that offers additional benefits in managing EGFRI-related paronychia. Further studies with longer follow-ups and improved patient compliance may help fully evaluate its effectiveness in pain reduction.</p>\n <p><b>Trial Registration</b>: ClinicalTrials.gov identifier: NCT06411093</p>\n </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/7019466","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatologic Therapy","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/dth/7019466","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
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Abstract
Background: Current therapies for epidermal growth factor receptor inhibitor (EGFRI)–related paronychia demonstrate effectiveness; however, some patients respond poorly and experience recurrent painful granulation tissue, particularly in weight-bearing areas such as the big toes. Based on promising results from our previous pilot study by Hsu and colleagues, novel kinesiology tape wrapping, which physically shields the inflamed periungual tissue from irritation by the nail plate, has emerged as a potentially effective adjunct therapy.
Objectives: This open-label, randomized-controlled, single-center study was aimed to evaluate the efficacy and safety of kinesiology tape wrapping in cancer patients with EGFRI-related paronychia.
Materials and Methods: Eligible participants were assigned to receive either kinesiology tape wrapping in combination with conventional therapies or conventional therapies alone for 12 weeks. Efficacy outcomes, including the reduction of subjective pain assessed by the numerical rating scale (NRS) and the objective single-digit scoring system for paronychia related to oncologic treatments (single-digit SPOT), as well as adverse events (AEs), were recorded at baseline and at Weeks 1, 2, 4, 8, and 12 postenrollment.
Results: A total of 24 patients were randomized, of which, 22 qualified for analysis. The rate of continuous tape use was 36.3%. At Week 12, pain NRS scores showed no significant differences between groups, while patients treated with continuous or intermittent kinesiology tape wrapping demonstrated notably greater reductions in single-digit SPOT scores compared to those receiving conventional therapy alone (NRS: 3.27 vs. 2.78, p = 0.586; single-digit SPOT: 5.32 vs. 1.52, p = 0.022). No serious AEs were reported.
Conclusion: Kinesiology tape wrapping is an effective and safe adjunct noninvasive therapy that offers additional benefits in managing EGFRI-related paronychia. Further studies with longer follow-ups and improved patient compliance may help fully evaluate its effectiveness in pain reduction.
背景：目前治疗表皮生长因子受体抑制剂（EGFRI）相关甲沟炎的方法是有效的；然而，一些患者反应不佳，反复出现肉芽组织疼痛，特别是在大脚趾等负重区域。基于Hsu和他的同事先前的初步研究的结果，新的运动学胶带包装，物理地保护发炎的趾周组织免受甲板的刺激，已经成为一种潜在有效的辅助治疗方法。目的：这项开放标签、随机对照、单中心研究旨在评估运动学胶带包裹治疗egfr相关性甲沟炎的疗效和安全性。材料和方法：符合条件的参与者被分配接受运动机能学胶带包装联合常规疗法或单独常规疗法，为期12周。在基线和入组后第1、2、4、8和12周记录疗效结果，包括通过数字评定量表（NRS）和与肿瘤治疗相关的甲沟炎客观个位数评分系统（single-digit SPOT）评估的主观疼痛减少，以及不良事件（ae）。结果：共纳入24例患者，其中22例符合分析条件。连续胶带使用率为36.3%。在第12周，疼痛NRS评分在两组间无显著差异，而连续或间歇运动机学胶带包扎治疗的患者与单独接受常规治疗的患者相比，其个位数SPOT评分明显降低(NRS: 3.27 vs. 2.78, p = 0.586；个位数SPOT: 5.32 vs. 1.52, p = 0.022)。没有严重的ae报告。结论：运动机能学胶带包扎是一种有效、安全的辅助无创治疗方法，在治疗egfr相关甲沟炎方面有额外的好处。通过更长时间的随访和患者依从性的改善，进一步的研究可能有助于充分评估其减轻疼痛的有效性。试验注册：ClinicalTrials.gov标识符：NCT06411093
期刊介绍：
Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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