Effect of Hypromellose Acetate Succinate and Sorbitan Monolaurate on the Properties and Bioactivity of Ternary Lycopene Amorphous Solid Dispersions

IF 3.4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Food Science Pub Date : 2025-06-24 DOI:10.1111/1750-3841.70355

Jianshuo Su, Yinglan Li, Shufan Liu, Sisi Liu, Huaizhen Zhang, Zhuang Ding, Min Liu, Yanna Zhao

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引用次数: 0

Abstract

ABSTRACT

In this study, ternary lycopene amorphous solid dispersions (LYC ASDs) were successfully prepared using hypromellose acetate succinate HF (HPMCAS-HF) and sorbitan monolaurate (Span 20). Differential scanning calorimetry (DSC) thermograms showed that no typical crystalline melting endotherm of LYC was observed, whereas powder x-ray diffraction (PXRD) patterns corroborated these findings by showing complete disappearance of patterns associated with crystalline LYC. Fourier transform infrared (FT-IR) spectroscopic analysis uncovered potential intermolecular interactions, including hydrophobic interaction and hydrogen bonds, between the drug and excipients. Homogeneous morphology was displayed in the scanning electron microscopy (SEM) images of LYC ASDs with a series of nanotopographies distributed on their rough surface. LYC ASDs exhibited enhanced in vitro radical scavenging capacity, whereas their excellent cellular reactive oxygen species (ROS) scavenging capacity was proved in both LO2 and Caco-2 cells. Besides, LYC ASDs possessed superior biocompatibility as their cytotoxicity against LO2 and Caco-2 cells was negligible, and their cell adhesion and migration were not affected by LYC ASDs. Furthermore, LYC ASDs markedly alleviated metabolic dysregulation, oxidative stress, and hepatic damage in a high-fat diet-induced liver injury model. In summary, LYC ASDs exhibited enormous potential for boosting the biopharmaceutical manifestation of similar hydrophobic bioactivates in the functional food field.

Practical Application

In this study, the effect of hypromellose acetate succinate HF and sorbitan monolaurate on the physicochemical properties and bioactivity of ternary lycopene amorphous solid dispersions was investigated. Therefore, this study provides a theoretical basis for the industrial application of lycopene-containing functional food products.

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琥珀酸羟丙纤维素和单月桂酸山梨糖对三元番茄红素非晶固体分散体性能和生物活性的影响

摘要本研究成功制备了三元番茄红素无定形固体分散体（LYC ASDs），其主要原料为醋酸琥珀酸羟丙甲糖HF （HPMCAS-HF）和单月梨酸山梨醇（Span 20）。差示扫描量热（DSC）热图显示，没有观察到LYC典型的晶体熔化恒温现象，而粉末x射线衍射（PXRD）图显示LYC晶体相关的模式完全消失，证实了这些发现。傅里叶变换红外（FT-IR）光谱分析揭示了药物和赋形剂之间潜在的分子间相互作用，包括疏水相互作用和氢键。LYC asd的扫描电镜（SEM）图像显示出均匀的形貌，在其粗糙的表面上分布着一系列纳米形貌。LYC ASDs具有较强的体外自由基清除能力，而其良好的细胞活性氧（ROS）清除能力在LO2和Caco-2细胞中均得到证实。此外，LYC ASDs对LO2和Caco-2细胞的细胞毒性可以忽略不计，且LYC ASDs对LO2和Caco-2细胞的粘附和迁移不受影响，具有较好的生物相容性。此外，LYC ASDs可显著缓解高脂饮食引起的肝损伤模型中的代谢失调、氧化应激和肝损伤。综上所述，LYC asd在促进类似疏水生物活性物在功能食品领域的生物制药表现方面具有巨大的潜力。本研究考察了醋酸琥珀酸氢丙纤维素和单月桂酸山梨糖对三元番茄红素非晶固体分散体理化性质和生物活性的影响。因此，本研究为含番茄红素功能性食品的产业化应用提供了理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Food Science 工程技术-食品科技

CiteScore

7.10

自引率

2.60%

发文量

412

审稿时长

3.1 months

期刊介绍： The goal of the Journal of Food Science is to offer scientists, researchers, and other food professionals the opportunity to share knowledge of scientific advancements in the myriad disciplines affecting their work, through a respected peer-reviewed publication. The Journal of Food Science serves as an international forum for vital research and developments in food science. The range of topics covered in the journal include: -Concise Reviews and Hypotheses in Food Science -New Horizons in Food Research -Integrated Food Science -Food Chemistry -Food Engineering, Materials Science, and Nanotechnology -Food Microbiology and Safety -Sensory and Consumer Sciences -Health, Nutrition, and Food -Toxicology and Chemical Food Safety The Journal of Food Science publishes peer-reviewed articles that cover all aspects of food science, including safety and nutrition. Reviews should be 15 to 50 typewritten pages (including tables, figures, and references), should provide in-depth coverage of a narrowly defined topic, and should embody careful evaluation (weaknesses, strengths, explanation of discrepancies in results among similar studies) of all pertinent studies, so that insightful interpretations and conclusions can be presented. Hypothesis papers are especially appropriate in pioneering areas of research or important areas that are afflicted by scientific controversy.