CALLA-negative, TdT- and CD7-positive acute lymphoblastic leukemia: a phenotype associated with poor prognosis.

Diagnostic and clinical immunology Pub Date : 1987-01-01
G De Rossi, M A Aloe Spiriti, A Cafolla, R Gastaldi, F Lo Coco, M Lopez, M Luciani, D Pasqualetti, A M Testi, F Mandelli
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Abstract

Eight ALL patients displaying a CD7+, Tdt+, CD10-, T MoAbs-, myeloid MoAbs-, AP+ phenotype are described. Some patients showed well-known risk factors such as cytogenetic abnormalities, high WBC count, mediastinal mass, and/or organomegalies. The clinical behaviour was very poor and only one patient is in CR and off therapy. Therefore such a pre-T phenotype, although sometimes associated with the other risk factors, could be considered a poor prognosis phenotype.

calla阴性、TdT-和cd7阳性的急性淋巴细胞白血病:一种与不良预后相关的表型
8例ALL患者表现为CD7+、Tdt+、CD10-、T MoAbs-、髓系MoAbs-、AP+表型。一些患者表现出众所周知的危险因素,如细胞遗传学异常、白细胞计数高、纵隔肿块和/或器官肿大。临床行为很差,只有1例患者处于CR期并停止治疗。因此,这种t前表型虽然有时与其他危险因素相关,但可被认为是预后不良的表型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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