The Cu and ligand free in situ nano Pd-catalysis: Simple and efficient one-pot synthesis of substituted isoquinolines in PEG-400

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry Pub Date : 2025-06-14 DOI:10.1016/j.jorganchem.2025.123738

Battini Geetha Rani , Sreedhar Gundekari , Shekhar Reddy Mulka , Chandra Sekhar Vasam , Narasimha Swamy Thirukovela

引用次数: 0

Abstract

In the present work, we described, a simple and efficient in situ palladium nanoparticles (PdNPs) in polyethylene glycol-400 (PEG-400) catalyzed tandem one-pot three-component reaction of ortho-bromobenzaldehydes, terminal alkynes and tert‑butylamine to afford substituted isoquinolines at mild temperature. Notably, these reactions were carried out under ligand- and Cu free-conditions. The in situ formation of PdNPs PEG-400 was confirmed by TEM and EDX techniques. Further, the role of in situ PdNPs to catalyze the sequential Sonogashira coupling and intramolecular cyclization was demonstrated. Finally, the in situ PdNPs obtained after first catalytic cycle were reused for further five times consecutively.

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无铜配体的原位纳米钯催化：PEG-400中一锅简单高效的取代异喹啉类化合物的合成

在本研究中，我们描述了一种简单高效的原位钯纳米颗粒（PdNPs）在聚乙二醇-400 （PEG-400）中催化邻溴苯甲醛、末端炔和叔丁胺的串联一锅三组分反应，在温和的温度下得到取代的异喹啉。值得注意的是，这些反应是在配体和铜自由条件下进行的。通过TEM和EDX技术证实了PdNPs PEG-400的原位形成。此外，原位PdNPs在催化顺序Sonogashira偶联和分子内环化中的作用得到了证实。最后，在第一次催化循环后获得的原位PdNPs连续重复使用5次。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.