Blocking adherence of Candida albicans to buccal epithelial cells by yeast glycolipids, yeast wall lipids and lipids from epithelial cells.

Abstract

Summary: Ceramide monohexosides and ceramide dihexosides isolated from total lipids of yeast forms of Candida albicans and steryl glycosides isolated from mycelial forms inhibited the adherence of yeast cells to buccal epithelial cells by 48,49 and 54%, respectively. Total lipids extracted from a membrane‐free preparation of yeast cell walls and from whole epithelial cells also blocked adherence by 57 and 53%. The lipid extracts were analyzed and found to contain various classes that inhibited adherence. These results support and contribute to our earlier findings indicating that surface lipids from yeast and epithelial cells may be involved in their mutual adherence.