Cholestatic diseases of liver transplantation.

Seminars in gastrointestinal disease Pub Date : 2001-04-01
M A Heneghan, P B Sylvestre
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引用次数: 0

Abstract

Cholestasis is a common finding after liver transplantation and usually signifies graft dysfunction. The most important factor in the evaluation of patients with cholestasis is an awareness of the disorders that commonly arise along a time continuum post-transplant. Therefore, the approach to cholestasis requires a systematic review of biochemical, histological, and radiographic data. This article considers the causes of cholestasis in liver transplant recipients, excluding those associated with biliary anastomotic stricturing. These causes include conditions as diverse as ischemia reperfusion injury, ABO blood group incompatibility, hepatic arterial thrombosis, cytomegalovirus infection, fibrosing cholestatic hepatitis secondary to hepatitis B and C viruses, recurrent primary sclerosing cholangitis, recurrent primary biliary cirrhosis, and chronic rejection. Also examined are management issues pertinent to these conditions and strategies used in preventing or diminishing the effects of cholestasis once established.

肝移植的胆汁淤积性疾病。
胆汁淤积是肝移植后常见的发现,通常表明移植物功能障碍。评估胆汁淤积症患者最重要的因素是对移植后一段时间内通常出现的疾病的认识。因此,胆汁淤积的方法需要对生化、组织学和放射学资料进行系统的回顾。本文考虑肝移植受者胆汁淤积的原因,不包括与胆道吻合口狭窄相关的原因。这些原因包括多种情况,如缺血再灌注损伤、ABO血型不相容、肝动脉血栓形成、巨细胞病毒感染、乙型和丙型肝炎病毒继发的纤维化胆汁淤积性肝炎、复发性原发性硬化性胆管炎、复发性原发性胆汁性肝硬化和慢性排斥反应。还检查了与这些条件和策略有关的管理问题,用于预防或减少一旦建立的胆汁淤积的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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