Correction to “lncRNA XLOC013218 Promotes Cell Proliferation and TMZ Resistance by Targeting the PIK3R2-Mediated PI3K/AKT Pathway in Glioma”

IF 4.3 2区 医学 Q1 ONCOLOGY
Cancer Science Pub Date : 2025-06-23 DOI:10.1111/cas.70131
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引用次数: 0

Abstract

Zhou J, Xu N, Liu B, et al. lncRNA XLOC013218 promotes cell proliferation and TMZ resistance by targeting the PIK3R2-mediated PI3K/AKT pathway in glioma. Cancer Sci. 2022; 113:2681–2692. doi:10.1111/cas.15387

In “3 | RESULTS” section, the text “3.4 | PIK3R2 knockdown reverses the enhanced TMZ sensitivity and promotes the cell survivability effect of XLOC” was incorrect.

This should have read: “3.4 | PIK3R2 knockdown partly reverses XLOC-mediated TMZ resistance in GBM cells”.

In “3.4 | PIK3R2 knockdown reverses the enhanced TMZ sensitivity and promotes the cell survivability effect of XLOC” section, the text “To further explore whether PIK3R2 is involved in the effect of XLOC or not, sh-PIK3R2 were transfected into cells stably overexpressing XLOC (U87 and U251 V-XLOC) (Figure 4A). Knockdown of PIK3R2 significantly decreased the sensitivity of GBM cells to TMZ with lower IC50 values (Figure 4B) and suppressed cell viability with TMZ (50μg/ml) treatment when compared with the control groups (Figure 4C, D).” was incorrect.

This should have read: “To further explore whether PIK3R2 is involved in the effect of XLOC, sh-PIK3R2 was transfected into cells stably overexpressing XLOC (U87 and U251 V-XLOC) (Figure 4A). Knockdown of PIK3R2 significantly increased the sensitivity of GBM cells to TMZ, as indicated by lower IC50 values (Figure 4B), and reduced cell viability upon TMZ (50μg/ml) treatment compared to the control groups (Figure 4C, D).”

In “3.7 | XLOC as a candidate therapeutic target” section, the text “Immunohistochemistry analysis revealed that PIK3R2 and Ki67 expression was weakly detected, whereas increased C-Cas3 expression was observed in XLOC-overexpressed tumor tissues.” was incorrect.

This should have read: “Immunohistochemistry analysis revealed that PIK3R2 and Ki67 expression was increased, whereas C-Cas3 expression was suppressed in XLOC-overexpressed tumor tissues.”

In “3.3 | PIK3R2 is the potential target of XLOC” section, the text “To determine the subcellular localization of XLOC, RNA in situ hybridization (RNA-ISH) was conducted” is incorrect.

This should have read: “FISH was conducted to determine the subcellular localization of XLOC”.

In “Figure 1” caption, the text “*p < 0.05, **p < 0.01, ***p < 0.001” is incorrect.

This should have read: “*p < 0.05, ***p < 0.001”.

We apologize for these errors.

Abstract Image

更正“lncRNA XLOC013218通过靶向胶质瘤中pik3r2介导的PI3K/AKT通路促进细胞增殖和TMZ耐药”。
周健,徐宁,刘波,等。lncRNA XLOC013218通过靶向pik3r2介导的PI3K/AKT通路促进胶质瘤细胞增殖和TMZ耐药。癌症科学,2022;113:2681 - 2692。doi: 10.1111 / ca。15387在“3| RESULTS”一节中,“3.4 | PIK3R2敲低逆转增强的TMZ敏感性并促进XLOC的细胞存活效应”的文本是不正确的。这应该是:“3.4 | PIK3R2敲低部分逆转了GBM细胞中xloc介导的TMZ耐药性”。在“3.4 | PIK3R2敲低逆转TMZ敏感性增强并促进XLOC细胞存活效应”一节中,“为了进一步探讨PIK3R2是否参与XLOC的作用,我们将sh-PIK3R2转染到稳定过表达XLOC的细胞(U87和U251 V-XLOC)中(图4A)。”敲低PIK3R2显著降低GBM细胞对TMZ的敏感性,IC50值较低(图4B),与对照组相比,TMZ (50μg/ml)处理抑制了细胞活力(图4C, D)。应该是:“为了进一步探索PIK3R2是否参与XLOC的作用,将sh-PIK3R2转染到稳定过表达XLOC的细胞中(U87和U251 V-XLOC)(图4A)。PIK3R2的敲低显著增加了GBM细胞对TMZ的敏感性,如较低的IC50值所示(图4B),并且与对照组相比,TMZ (50μg/ml)处理降低了细胞活力(图4C, D)。在“3.7 bb0 XLOC作为候选治疗靶点”一节中,文本“免疫组织化学分析显示PIK3R2和Ki67表达较弱,而在XLOC过表达的肿瘤组织中观察到C-Cas3表达增加”是不正确的。这应该是:“免疫组织化学分析显示,在xloc过表达的肿瘤组织中,PIK3R2和Ki67的表达增加,而C-Cas3的表达被抑制。”在“3.3 | PIK3R2是XLOC的潜在靶标”一节中,文本“为了确定XLOC的亚细胞定位,进行了RNA原位杂交(RNA- ish)”是不正确的。这应该是:“FISH被用于确定XLOC的亚细胞定位”。在“图1”标题,文本”* p & lt; 0.05 * * p & lt; 0.01 * * * p & lt; 0.001”是不正确的。这应该读过:“* p & lt; 0.05 * * * p & lt; 0.001”。我们为这些错误道歉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer Science
Cancer Science 医学-肿瘤学
自引率
3.50%
发文量
406
审稿时长
2 months
期刊介绍: Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.
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