Trends, disparities, and outcomes of drug-induced pancreatitis in the United States: A nationwide analysis (2016–2020)

IF 2.6 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2025-06-20 DOI:10.1016/j.clinre.2025.102641

Guy Loic Nguefang Tchoukeu , Sarpong Boateng , Joel Gabin Konlack Mekontso , Yazan A Al-Ajlouni , Basile Njei

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引用次数: 0

Abstract

Background

Drug-induced pancreatitis (DIP) is an underreported etiology of acute pancreatitis. DIP risk and prevalence has increased over the years with polypharmacy. Data on affected patients in the U.S. remain limited. We aim to assess disparities and outcomes in DIP hospitalizations.

Methods

Retrospective study including adults diagnosed with DIP using the National Inpatient Sample (NIS) database (2016–2020). The primary outcomes were inpatient mortality, and complications. Secondary outcomes included resource utilization metrics. Descriptive statistics, linear regression, and logistic regression were performed using SAS 9.4.

Results

5666 patients (mean age: 56.5 years; females 53.6 %) were included. Common comorbidities were hypertension (61.3 %), hyperlipidemia (42.3 %), and diabetes (22.9 %). The mortality rate was 1.5 %, with acute kidney injury (20.6 %), Sepsis (5.0 %), ileus (3.5 %) the common complications. The Mean LOS was 5.5 days, and the mean hospital charges were $60,811.20. Compared to White, Hispanics had significant odds of DIP admission (aOR: 1.11, 95 % CI: 1.01–1.21, p = 0.03) and increased risk of cardiac arrest (aOR 4.34, 95 % CI 1.17–15.35, p = 0.02). Black patients had significantly higher odds of severe DIP (aOR 1.26, 95 % CI 1.02–1.56, p = 0.03) and acute kidney injury (aOR 1.29, 95 % CI 1.04–1.61, p = 0.02), while Asian were more likely to develop sepsis (aOR 2.10, 95 % CI 1.07–3.83, p = 0.02), had higher hospital charges (+$42,008, p = 0.039) and longer LOS (+2.5 days, p < 0.01)..

Conclusion

There are significant racial disparities among patients and a substantial economic burden on healthcare systems. Multifaceted strategies and research into genetic and socioeconomic predispositions are needed to address DIP.

查看原文本刊更多论文

美国药物性胰腺炎的趋势、差异和结果：一项全国性分析（2016-2020）。

背景：药物性胰腺炎（DIP）是一种被低估的急性胰腺炎病因。多年来，多药联用增加了DIP的风险和患病率。美国受影响患者的数据仍然有限。我们的目的是评估DIP住院治疗的差异和结果。方法：采用2016-2020年国家住院患者样本（NIS）数据库对诊断为DIP的成年人进行回顾性研究。主要结局是住院死亡率和并发症。次要结果包括资源利用指标。采用SAS 9.4进行描述性统计、线性回归和逻辑回归。结果：5666例患者(平均年龄56.5岁；女性53.6%)。常见的合并症是高血压（61.3%）、高脂血症（42.3%）和糖尿病（22.9%）。死亡率为1.5%，常见并发症为急性肾损伤（20.6%）、脓毒症（5.0%）、肠梗阻（3.5%）。平均住院时间为5.5天，平均住院费用为60 811.20美元。与白人相比，西班牙裔患者有显著的DIP入院几率（aOR: 1.11, 95% CI: 1.01-1.21, p = 0.03）和增加的心脏骤停风险（aOR 4.34, 95% CI 1.17-15.35, p=0.02）。黑人患者发生严重DIP （aOR 1.26, 95% CI 1.02-1.56, p=0.03）和急性肾损伤（aOR 1.29, 95% CI 1.04-1.61, p=0.02）的几率明显更高，而亚洲人更容易发生败血症（aOR 2.10, 95% CI 1.07-3.83, p=0.02），住院费用更高（+ 42008美元，p=0.039），住院时间更长（+2.5天，p）。结论：患者之间存在显著的种族差异，给医疗保健系统带来了巨大的经济负担。要解决DIP问题，需要采取多方面的战略并对遗传和社会经济倾向进行研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.