Finite-time stability analysis of interacting genetic regulatory networks with spatial diffusion term

IF 7 2区 医学 Q1 BIOLOGY
Qi Liu , Zhiqiang Lv , Chengye Zou , Hao Zhang
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引用次数: 0

Abstract

This paper explores the finite-time stable behavior of interacting genetic regulatory networks (GRNs) incorporating spatial diffusion terms under Dirichlet boundary conditions. We propose a coupled model of interacting GRNs and a novel Lyapunov-Krasovskii functional to analyze the dynamic evolution of interactions between the two systems. The lower bound of the time delay can be either zero or non-zero. By employing a delay partitioning approach, we derive less conservative stability criteria for the interacting systems. Finally, numerical simulations are conducted, and the trajectories of mRNA and protein concentrations are provided to validate the accuracy of the proposed criteria.
具有空间扩散项的相互作用遗传调控网络的有限时间稳定性分析
本文研究了Dirichlet边界条件下包含空间扩散项的相互作用遗传调控网络(GRNs)的有限时间稳定行为。我们提出了一个相互作用的grn的耦合模型和一个新的Lyapunov-Krasovskii泛函来分析两个系统之间相互作用的动态演化。时间延迟的下界可以是零,也可以是非零。通过采用延迟划分方法,我们得到了相互作用系统的不太保守的稳定性准则。最后,进行了数值模拟,并提供了mRNA和蛋白质浓度的轨迹来验证所提出标准的准确性。
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来源期刊
Computers in biology and medicine
Computers in biology and medicine 工程技术-工程:生物医学
CiteScore
11.70
自引率
10.40%
发文量
1086
审稿时长
74 days
期刊介绍: Computers in Biology and Medicine is an international forum for sharing groundbreaking advancements in the use of computers in bioscience and medicine. This journal serves as a medium for communicating essential research, instruction, ideas, and information regarding the rapidly evolving field of computer applications in these domains. By encouraging the exchange of knowledge, we aim to facilitate progress and innovation in the utilization of computers in biology and medicine.
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