Difunctionalization of Sulfamate-Derived Cyclic Imines through Phosphine Catalysis

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-22 DOI:10.1021/acs.orglett.5c01703

Yaping Wang, Bing Zheng*, Jiawei Liu, Siting Qu, Shicong Hou, Leijie Zhou* and Hongchao Guo*,

引用次数: 0

Abstract

With the use of alkynyl 1,2-diones as phosphine acceptors and H₂O as a reaction partner, an unprecedented phosphine-catalyzed three-component difunctionalization of sulfamate-derived cyclic imines was achieved, providing a wide range of highly functionalized cyclic sulfonamide products in moderate to good yields. This protocol features a broad substrate scope and mild reaction conditions. It also represents a rare example of H₂O serving as a substrate to participate in phosphine-catalyzed reactions. The reaction mechanism involves a tandem acyloxylation/cinnamoylation reaction.

Abstract Image

查看原文本刊更多论文

膦催化磺胺衍生物环亚胺的双官能化

以炔基1,2-二酮为膦受体，H2O为反应伙伴，实现了前所未有的膦催化磺胺衍生物环亚胺三组分双官能化反应，以中高收率获得了广泛的高官能化环磺酰胺产品。该工艺的特点是底物范围广，反应条件温和。它也代表了H2O作为底物参与膦催化反应的罕见例子。反应机理为乙酰氧基化/肉桂基化串联反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.