{"title":"Rh-Catalyzed Hydroformylation of Benzylidenecyclopropanes with Formic Acid","authors":"Junhua Li, Guoqing Li, Jing Li, Yian Shi","doi":"10.1021/acs.orglett.5c01658","DOIUrl":null,"url":null,"abstract":"A Rh-catalyzed hydroformylation of benzylidenecyclopropanes with HCO<sub>2</sub>H/Ac<sub>2</sub>O is described. A wide variety of ring-opening linear γ,δ-unsaturated aldehydes or 2-cyclopropyl-2-arylacetaldehydes can be obtained in up to 82% or 70% yield, respectively, by a judicious choice of the reaction conditions. The reaction is operationally simple and avoids the use of gaseous CO and H<sub>2</sub>.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"8 1","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Letters","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.orglett.5c01658","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A Rh-catalyzed hydroformylation of benzylidenecyclopropanes with HCO2H/Ac2O is described. A wide variety of ring-opening linear γ,δ-unsaturated aldehydes or 2-cyclopropyl-2-arylacetaldehydes can be obtained in up to 82% or 70% yield, respectively, by a judicious choice of the reaction conditions. The reaction is operationally simple and avoids the use of gaseous CO and H2.
期刊介绍:
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.