Rh-Catalyzed Hydroformylation of Benzylidenecyclopropanes with Formic Acid

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-23 DOI:10.1021/acs.orglett.5c01658

Junhua Li, Guoqing Li, Jing Li, Yian Shi

引用次数: 0

Abstract

A Rh-catalyzed hydroformylation of benzylidenecyclopropanes with HCO₂H/Ac₂O is described. A wide variety of ring-opening linear γ,δ-unsaturated aldehydes or 2-cyclopropyl-2-arylacetaldehydes can be obtained in up to 82% or 70% yield, respectively, by a judicious choice of the reaction conditions. The reaction is operationally simple and avoids the use of gaseous CO and H₂.

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甲酸催化苄基环丙烷的氢甲酰化反应

研究了以HCO2H/Ac2O催化苄基环丙烷的氢甲酰化反应。通过合理选择反应条件，可制得各种开环型γ、δ-不饱和醛或2-环丙基-2-芳基乙醛，产率分别可达82%或70%。该反应操作简单，避免了气态CO和H2的使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.