Potassium chloride intracardiac fetal injection and tissue degeneration at fetal autopsy following induction abortion

IF 2.3 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Contraception Pub Date : 2025-06-19 DOI:10.1016/j.contraception.2025.110986

Kelvin Chui , Jefferson Terry , Jennifer A. Hutcheon , Chantal Mayer , Jessica Liauw

{"title":"Potassium chloride intracardiac fetal injection and tissue degeneration at fetal autopsy following induction abortion","authors":"Kelvin Chui , Jefferson Terry , Jennifer A. Hutcheon , Chantal Mayer , Jessica Liauw","doi":"10.1016/j.contraception.2025.110986","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the impact of potassium chloride intracardiac injection (KCl) on tissue degeneration at fetal autopsy, which may help inform termination care and autopsy expectations.</div></div><div><h3>Study design</h3><div>In this retrospective cohort of induction abortions with fetal autopsies (<em>N</em> = 266), we estimated the association between KCl and fetal tissue degeneration (qualitative assessment and quantitative ratio of basophilia:eosinophilia). We used log binomal and linear regression to calculate risk ratios and mean differences with 95% confidence intervals.</div></div><div><h3>Results</h3><div>Those who received KCl were more likely to have qualitative tissue degeneration than those who did not (RR 2.8 [95% CI 1.3–6.1]). Quantitative basophilia:eosinophilia ratios were lower among those with KCl (mean difference in cardiac tissues of −0.031 [95% CI −0.039 to −0.023]), which further supports increased tissue degeneration in these cases.</div></div><div><h3>Conclusions</h3><div>Fetal autopsies from induction abortions that had KCl fetal injection had increased risk of tissue degeneration compared with those that did not.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"150 ","pages":"Article 110986"},"PeriodicalIF":2.3000,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contraception","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010782425001775","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

To assess the impact of potassium chloride intracardiac injection (KCl) on tissue degeneration at fetal autopsy, which may help inform termination care and autopsy expectations.

Study design

In this retrospective cohort of induction abortions with fetal autopsies (N = 266), we estimated the association between KCl and fetal tissue degeneration (qualitative assessment and quantitative ratio of basophilia:eosinophilia). We used log binomal and linear regression to calculate risk ratios and mean differences with 95% confidence intervals.

Results

Those who received KCl were more likely to have qualitative tissue degeneration than those who did not (RR 2.8 [95% CI 1.3–6.1]). Quantitative basophilia:eosinophilia ratios were lower among those with KCl (mean difference in cardiac tissues of −0.031 [95% CI −0.039 to −0.023]), which further supports increased tissue degeneration in these cases.

Conclusions

Fetal autopsies from induction abortions that had KCl fetal injection had increased risk of tissue degeneration compared with those that did not.

查看原文本刊更多论文

胎心内注射氯化钾与引产后胎儿解剖的组织变性。

目的：评估心脏内注射氯化钾（KCl）对胎儿尸检时组织变性的影响，这可能有助于告知终止妊娠护理和尸检预期。研究设计：在这个有胎儿尸检的引产回顾性队列中（N=266），我们估计了KCl和胎儿组织变性之间的关系（嗜碱性粒细胞增多和嗜酸性粒细胞增多的定性评估和定量比例）。我们使用对数二项和线性回归计算风险比和95%置信区间的平均差异。结果：接受KCl治疗的患者比未接受KCl治疗的患者更容易发生定性组织变性（RR 2.8 [95% CI 1.3-6.1]）。定量嗜碱性粒细胞：嗜酸性粒细胞比例在KCl患者中较低（心脏组织的平均差异为-0.031 [95%CI -0.039至-0.023]），这进一步支持了这些病例中组织变性的增加。结论：引产胎儿解剖中注射KCl的胎儿与未注射KCl的胎儿相比，组织变性的风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Contraception 医学-妇产科学

CiteScore

4.70

自引率

17.20%

发文量

211

审稿时长

69 days

期刊介绍： Contraception has an open access mirror journal Contraception: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal Contraception wishes to advance reproductive health through the rapid publication of the best and most interesting new scholarship regarding contraception and related fields such as abortion. The journal welcomes manuscripts from investigators working in the laboratory, clinical and social sciences, as well as public health and health professions education.