Potassium chloride intracardiac fetal injection and tissue degeneration at fetal autopsy following induction abortion.

Contraception Pub Date : 2025-06-19 DOI:10.1016/j.contraception.2025.110986

Kelvin Chui, Jefferson Terry, Jennifer A Hutcheon, Chantal Mayer, Jessica Liauw

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引用次数: 0

Abstract

Objectives: To assess the impact of potassium chloride intracardiac injection (KCl) on tissue degeneration at fetal autopsy, which may help inform termination care and autopsy expectations.

Study design: In this retrospective cohort of induction abortions with fetal autopsies (N=266), we estimated the association between KCl and fetal tissue degeneration (qualitative assessment and quantitative ratio of basophilia:eosinophilia). We used log binomal and linear regression to calculate risk ratios and mean differences with 95% confidence intervals.

Results: Those who received KCl were more likely to have qualitative tissue degeneration than those who did not (RR 2.8 [95% CI 1.3-6.1]). Quantitative basophilia:eosinophilia ratios were lower among those with KCl (mean difference in cardiac tissues of -0.031 [95%CI -0.039 to -0.023]), which further supports increased tissue degeneration in these cases.

Conclusions: Fetal autopsies from induction abortions that had KCl fetal injection had increased risk of tissue degeneration compared with those that did not.

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胎心内注射氯化钾与引产后胎儿解剖的组织变性。

目的：评估心脏内注射氯化钾（KCl）对胎儿尸检时组织变性的影响，这可能有助于告知终止妊娠护理和尸检预期。研究设计：在这个有胎儿尸检的引产回顾性队列中（N=266），我们估计了KCl和胎儿组织变性之间的关系（嗜碱性粒细胞增多和嗜酸性粒细胞增多的定性评估和定量比例）。我们使用对数二项和线性回归计算风险比和95%置信区间的平均差异。结果：接受KCl治疗的患者比未接受KCl治疗的患者更容易发生定性组织变性（RR 2.8 [95% CI 1.3-6.1]）。定量嗜碱性粒细胞：嗜酸性粒细胞比例在KCl患者中较低（心脏组织的平均差异为-0.031 [95%CI -0.039至-0.023]），这进一步支持了这些病例中组织变性的增加。结论：引产胎儿解剖中注射KCl的胎儿与未注射KCl的胎儿相比，组织变性的风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Contraception

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