Left ventricular systolic function and mechanical ventilation weaning failure: An updated systematic review and meta-analysis with trial sequential analysis.
Cristina Santonocito, Simone Messina, Mateusz Zawadka, Pruszczyk Andrzej, Elena Bignami, Andrea Morelli, Sabino Scolletta, Alberto Noto, Filippo Sanfilippo
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引用次数: 0
Abstract
Objective: The impact of left ventricular (LV) systolic dysfunction on weaning failure is unclear.
Design: Updated meta-analysis assessing the association between LV ejection fraction (LVEF) and weaning failure.
Setting: A systematic search of MEDLINE and EMBASE for prospective studies reporting weaning according to echocardiographic data measured before starting a spontaneous breathing trial (SBT).
Patients or participants: Studies included in the meta-analysis that reported on weaning and echocardiographic data.
Main variables of interest: LVEF, E/e' ratio, E velocity, deceleration time of the E wave, and e' velocity.
Results: Three studies were added in this update (n = 14, sample 20-30% larger). Lower LVEF (n = 12) was associated with weaning failure: MD: -4.71 95%CI [-9.18, -0.23]; p = 0.04, I2 = 90%, low certainty of evidence), without subgroups difference according to SBT type or LVEF mean values. Trial sequential analysis showed that results were not robust (information size n = 745/1378). E/e' ratio (MD: 1.90, 95%CI [0.48,3.32]; p = 0.009, I2 = 84%), E velocity (MD: 8.32, 95%CI [2.59,14.05]; p = 0.004, I2 = 54%) and shorter deceleration time of the E wave (MD: -12.01, 95%CI [-21.13, -2.89]; p = 0.01, I2 = 0%) were associated with weaning failure, whilst e' velocity was not (MD: -0.59, 95%CI [-1.51,0.32]; p = 0.20, I2 = 64%).
Conclusions: An association of weaning failure with poorer LV systolic function (LVEF), not detected by the previous meta-analysis, was found. However, such association is highly fragile and with a mean difference below 5%, which seems not clinically relevant. Higher E/e' ratio and other diastolic parameters confirmed their association with weaning failure, whilst e' did not.