María-Lidón Mateu-Campos, Susana Altaba-Tena, Beatriz Boscá-Martínez, Jesús Camáñez-Fortanet, Clara Viana-Marco, Ana-Belén González-Núñez, Anna-Rosa Villanova-Landete, Fernando Sánchez-Morán, Raquel Navarro-Alcaraz
{"title":"Clinical impact of COVID-19 respiratory infection 15 months after intensive care unit discharge.","authors":"María-Lidón Mateu-Campos, Susana Altaba-Tena, Beatriz Boscá-Martínez, Jesús Camáñez-Fortanet, Clara Viana-Marco, Ana-Belén González-Núñez, Anna-Rosa Villanova-Landete, Fernando Sánchez-Morán, Raquel Navarro-Alcaraz","doi":"10.1016/j.medine.2025.502230","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To determine the prevalence of persistent COVID-19 symptoms in SARS-CoV-2 patients 15 months after ICU discharge,their impact on physical, psychological, and neurocognitive domains, and the burden on primary caregivers.</p><p><strong>Design: </strong>Descriptive, ambispective observational study.</p><p><strong>Setting: </strong>Intensive Care Unit from a tertiary-level hospital.</p><p><strong>Patients: </strong>SARS-CoV-2 patients discharged from ICU.</p><p><strong>Main variables of interest: </strong>demographics and hospitalization data. Questionnaires assesing persistent COVID symptoms, functional tests (6-Minute Walk Test), anxiety (Beck Anxiety Inventory), PTSD and Zarit Caregiver Burden scales. Statistical analysis was performed using Stata for Mac, version 14.2.</p><p><strong>Results: </strong>85 patients were evaluated, with a median age of 60.3 years (IQR 54.0-68.9), 70.6% males. A high percentage of patients reported musculoskeletal disorders such as arthralgia (44.7%) and myalgia (38.2%), cognitive impairments (52.9%), sleep disturbances (34.1%), asthenia (44.5%) and anxiety (34.5%). The overall BAI score was 2 (0-9), with paraesthesia being the most common symptom. Additionally, 29.4% of patients reported \"fear of the worst\", 35% had unpleasant or recurrent memories of their ICU stay, and 16.4% were unable to relax (moderate/severe degree). Interviews with primary caregivers revealed that 22.2% reported caregiving as a significant burden.</p><p><strong>Conclusions: </strong>persistent COVID affects three primary functional domains: physical, cognitive and psychological, as well as on primary caregivers concerns and burdens.</p>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502230"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina intensiva","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.medine.2025.502230","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: To determine the prevalence of persistent COVID-19 symptoms in SARS-CoV-2 patients 15 months after ICU discharge,their impact on physical, psychological, and neurocognitive domains, and the burden on primary caregivers.
Setting: Intensive Care Unit from a tertiary-level hospital.
Patients: SARS-CoV-2 patients discharged from ICU.
Main variables of interest: demographics and hospitalization data. Questionnaires assesing persistent COVID symptoms, functional tests (6-Minute Walk Test), anxiety (Beck Anxiety Inventory), PTSD and Zarit Caregiver Burden scales. Statistical analysis was performed using Stata for Mac, version 14.2.
Results: 85 patients were evaluated, with a median age of 60.3 years (IQR 54.0-68.9), 70.6% males. A high percentage of patients reported musculoskeletal disorders such as arthralgia (44.7%) and myalgia (38.2%), cognitive impairments (52.9%), sleep disturbances (34.1%), asthenia (44.5%) and anxiety (34.5%). The overall BAI score was 2 (0-9), with paraesthesia being the most common symptom. Additionally, 29.4% of patients reported "fear of the worst", 35% had unpleasant or recurrent memories of their ICU stay, and 16.4% were unable to relax (moderate/severe degree). Interviews with primary caregivers revealed that 22.2% reported caregiving as a significant burden.
Conclusions: persistent COVID affects three primary functional domains: physical, cognitive and psychological, as well as on primary caregivers concerns and burdens.