Clinical impact of COVID-19 respiratory infection 15 months after intensive care unit discharge.

María-Lidón Mateu-Campos, Susana Altaba-Tena, Beatriz Boscá-Martínez, Jesús Camáñez-Fortanet, Clara Viana-Marco, Ana-Belén González-Núñez, Anna-Rosa Villanova-Landete, Fernando Sánchez-Morán, Raquel Navarro-Alcaraz
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Abstract

Objectives: To determine the prevalence of persistent COVID-19 symptoms in SARS-CoV-2 patients 15 months after ICU discharge,their impact on physical, psychological, and neurocognitive domains, and the burden on primary caregivers.

Design: Descriptive, ambispective observational study.

Setting: Intensive Care Unit from a tertiary-level hospital.

Patients: SARS-CoV-2 patients discharged from ICU.

Main variables of interest: demographics and hospitalization data. Questionnaires assesing persistent COVID symptoms, functional tests (6-Minute Walk Test), anxiety (Beck Anxiety Inventory), PTSD and Zarit Caregiver Burden scales. Statistical analysis was performed using Stata for Mac, version 14.2.

Results: 85 patients were evaluated, with a median age of 60.3 years (IQR 54.0-68.9), 70.6% males. A high percentage of patients reported musculoskeletal disorders such as arthralgia (44.7%) and myalgia (38.2%), cognitive impairments (52.9%), sleep disturbances (34.1%), asthenia (44.5%) and anxiety (34.5%). The overall BAI score was 2 (0-9), with paraesthesia being the most common symptom. Additionally, 29.4% of patients reported "fear of the worst", 35% had unpleasant or recurrent memories of their ICU stay, and 16.4% were unable to relax (moderate/severe degree). Interviews with primary caregivers revealed that 22.2% reported caregiving as a significant burden.

Conclusions: persistent COVID affects three primary functional domains: physical, cognitive and psychological, as well as on primary caregivers concerns and burdens.

重症监护病房出院后15个月COVID-19呼吸道感染的临床影响
目的:了解SARS-CoV-2患者在ICU出院15个月后持续出现COVID-19症状的发生率、对身体、心理和神经认知领域的影响以及对主要护理人员的负担。设计:描述性、双视角观察研究。环境:三级医院重症监护室。患者:ICU出院的SARS-CoV-2患者。主要研究变量:人口统计数据和住院数据。评估持续COVID症状的问卷、功能测试(6分钟步行测试)、焦虑(贝克焦虑量表)、PTSD和Zarit照顾者负担量表。统计分析使用Stata for Mac, 14.2版本。结果:85例患者,中位年龄60.3岁(IQR 54.0 ~ 68.9),男性70.6%。较高比例的患者报告有肌肉骨骼疾病,如关节痛(44.7%)和肌痛(38.2%)、认知障碍(52.9%)、睡眠障碍(34.1%)、虚弱(44.5%)和焦虑(34.5%)。BAI总分为2分(0-9分),感觉异常是最常见的症状。此外,29.4%的患者报告“害怕最坏的情况”,35%的患者对ICU住院有不愉快或反复的记忆,16.4%的患者无法放松(中度/重度)。对主要照护者的访谈显示,22.2%的人表示照护是一项重大负担。结论:持续的COVID影响三个主要功能领域:身体、认知和心理,以及主要照顾者的担忧和负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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