The prognostic role of Geriatric 8 in patients with cancer: a meta-analysis and systematic review.

IF 4.8 2区医学 Q1 ONCOLOGY

Oncologist Pub Date : 2025-06-04 DOI:10.1093/oncolo/oyaf118

Runzhi Chen, Dongmei Yang, Mengxing Tian, Huiting Xu, Xin Jin

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引用次数: 0

Abstract

Objective: Previous studies have reported conflicting results regarding the association between the Geriatric 8 (G-8) geriatric screening tool and prognosis in patients with cancer. This meta-analysis aimed to evaluate the prognostic value of the G-8 score in patients with cancer.

Methods: PubMed, Cochrane Library, Embase, and Medline databases were searched to identify trials exploring the association between G-8 score and prognosis in patients with cancer. Meta-analyses of overall survival (OS) and progression-free survival (PFS) between the high and low G-8 scores were performed. The quality of the included studies was assessed using the Quality In Prognosis Studies tool.

Results: A total of 42 studies involving 9053 patients with cancer were included. The prevalence of frailty, evaluated using the G-8 tool across trials, ranged from 27% to 91%. A low G-8 score was associated with poor OS (Hazard ratio [HR] 2.11; 95% CI:1.93-2.31, P <.001) and PFS (HR 1.78, 95% CI,1.55-2.05, P <.001) in patients with cancer. Overall survival were shorter in patients with low G-8 scores than in those with high G-8 scores in digestive system tumors, head and neck cancer, lung cancer, gynecologic tumors, hematologic malignancies, and prostate cancer. The predictive role of the G-8 tool was also confirmed in subgroups with G-8 cutoff values of 9-14. Patients with low G-8 scores had more advanced disease stages and higher ECOG performance status scores.

Conclusions: The prevalence of frailty was high among patients with cancer according to the G-8 geriatric screening tool. Decreased G-8 scores are significantly associated with poor survival in patients with cancer. G-8 is a promising tool for frailty screening.

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老年8在癌症患者预后中的作用：荟萃分析和系统评价

目的：先前的研究报道了关于Geriatric 8 （G-8）老年筛查工具与癌症患者预后之间关系的相互矛盾的结果。本荟萃分析旨在评估G-8评分在癌症患者中的预后价值。方法：检索PubMed、Cochrane Library、Embase和Medline数据库，以确定探讨G-8评分与癌症患者预后之间关系的试验。对高、低G-8评分患者的总生存期（OS）和无进展生存期（PFS）进行meta分析。使用预后研究质量工具评估纳入研究的质量。结果：共纳入42项研究，涉及9053例癌症患者。在所有试验中使用G-8工具评估的虚弱患病率从27%到91%不等。G-8评分低与不良OS相关(风险比[HR] 2.11；95% CI:1.93-2.31， P结论：根据G-8老年筛查工具，癌症患者中虚弱的患病率较高。G-8评分降低与癌症患者的生存不良显著相关。G-8是一种很有前途的虚弱筛查工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncologist 医学-肿瘤学

CiteScore

10.40

自引率

3.40%

发文量

309

审稿时长

3-8 weeks

期刊介绍： The Oncologist® is dedicated to translating the latest research developments into the best multidimensional care for cancer patients. Thus, The Oncologist is committed to helping physicians excel in this ever-expanding environment through the publication of timely reviews, original studies, and commentaries on important developments. We believe that the practice of oncology requires both an understanding of a range of disciplines encompassing basic science related to cancer, translational research, and clinical practice, but also the socioeconomic and psychosocial factors that determine access to care and quality of life and function following cancer treatment.