Multimodal rehabilitation to improve quality of life and fatigue after radiotherapy in esophageal cancer patients: a randomized trial.

IF 4.8 2区医学 Q1 ONCOLOGY

Oncologist Pub Date : 2025-06-04 DOI:10.1093/oncolo/oyaf073

Xianyan Chen, Linjun Zhong, Jiao Wang, Tingting Dai, Mingxia Li, Jiao Luo, Lin Zhu, Xinchi Liu, Lin Tao, Linjuan Li, Hongyan Du, Ruyu Ge, Shiqi Tao, Cheng Yi, Yan Fu, Youling Gong

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引用次数: 0

Abstract

Purpose: To compare the effects of nurse-led multimodal rehabilitation with conventional rehabilitation on quality of life and physical recovery during adjuvant radiotherapy for postoperative esophageal cancer.

Methods: Seventy participants were randomized into a control group (N = 35) receiving conventional care and a multimodal group (N = 35) receiving nurse-led multimodal rehabilitation. Outcomes including quality of life, dyspnea index, fatigue, sleep quality, nutrition, anxiety, and depression status were recorded before the start of radiotherapy (T0), after completion of radiotherapy (T1), and 6 months (T2) and 12 months (T3) after completion of radiotherapy. Data were analyzed using intention-to-treat principles and linear mixed models.

Results: The multimodal group significantly increased the global health scores compared to the control group at T1 (p < 0.001), with differences remaining significant at T2 (p = 0.002) and T3 (p = 0.005). The weight of the multimodal group was also significantly higher than that of the control group at T1 (p = 0.008), with the difference remaining significant at T2 (p = 0.033) and T3 (p = 0.020). The fatigue score of the multimodal group decreased significantly at T1 (p < 0.001) and remained significant at T2 (p < 0.001) and T3 (p = 0.005). The anxiety and depression status of the multimodal group improved significantly at T1, and the difference remained significant at T2 (all p < 0.05).

Conclusion: Nurse-led multimodal rehabilitation significantly improved quality of life, sleep quality, nutrition, fatigue, anxiety, and depression status in patients undergoing postoperative radiotherapy for esophageal cancer.

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多模式康复改善食管癌患者放疗后的生活质量和疲劳：一项随机试验。

目的：比较护士主导的多模式康复与常规康复对食管癌术后辅助放疗患者生活质量和身体恢复的影响。方法：70名参与者随机分为对照组（N = 35）和多模式组（N = 35），分别接受常规护理和护士主导的多模式康复治疗。记录放疗开始前（T0）、放疗结束后（T1）、放疗结束后6个月（T2）和12个月（T3）患者的生活质量、呼吸困难指数、疲劳、睡眠质量、营养状况、焦虑和抑郁状况。使用意向治疗原则和线性混合模型分析数据。结果：与对照组相比，多模式组在T1时的整体健康评分显著提高(p)。结论：护士主导的多模式康复显著改善了食管癌术后放疗患者的生活质量、睡眠质量、营养、疲劳、焦虑和抑郁状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncologist 医学-肿瘤学

CiteScore

10.40

自引率

3.40%

发文量

309

审稿时长

3-8 weeks

期刊介绍： The Oncologist® is dedicated to translating the latest research developments into the best multidimensional care for cancer patients. Thus, The Oncologist is committed to helping physicians excel in this ever-expanding environment through the publication of timely reviews, original studies, and commentaries on important developments. We believe that the practice of oncology requires both an understanding of a range of disciplines encompassing basic science related to cancer, translational research, and clinical practice, but also the socioeconomic and psychosocial factors that determine access to care and quality of life and function following cancer treatment.