The bone-heart axis: A crucial dialogue in cardiovascular disease

IF 10.8 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Metabolism: clinical and experimental Pub Date : 2025-06-19 DOI:10.1016/j.metabol.2025.156332

Ying Liu , Qi Yao , Jiabin Yu, Yadan Zhang, Yang Xiao, Nan Zhang, Qi-Zhu Tang

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Abstract

Cardiovascular diseases (CVDs), the leading cause of global mortality, are now understood to be profoundly influenced by the endocrine regulatory functions of the skeletal system. Emerging evidence suggests that osteocrine factors, including fibroblast growth factor-23 (FGF23), lipocalin-2 (LCN2), Dickkopf-1 (DKK1), myeloid-derived growth factor (MYDGF), osteocalcin (OCN), and sclerostin (SOST), establish bidirectional regulatory networks with the cardiovascular system, termed the “bone-heart axis”. This axis regulates critical pathological processes, including mineral metabolism, vascular calcification, and myocardial energy homeostasis. Dysregulation of this crosstalk accelerates the progression of atherosclerosis (AS), heart failure (HF), and other CVDs. Therefore, current research necessitates a paradigm shift from univariate analyses to elucidating the spatiotemporal dynamics of interorgan communication, thereby facilitating the development of precision therapeutic strategies for integrated skeletal and cardiovascular protection.

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骨-心轴：心血管疾病的关键对话。

心血管疾病（cvd），全球死亡的主要原因，现在被理解为深刻地影响骨骼系统的内分泌调节功能。新出现的证据表明，骨分泌因子，包括成纤维细胞生长因子-23 （FGF23）、脂钙素-2 （LCN2）、Dickkopf-1 （DKK1）、髓源性生长因子（MYDGF）、骨钙素（OCN）和硬化蛋白（SOST），与心血管系统建立了双向调节网络，称为“骨-心轴”。这条轴调节关键的病理过程，包括矿物质代谢、血管钙化和心肌能量稳态。这种串扰的失调加速了动脉粥样硬化（AS）、心力衰竭（HF）和其他心血管疾病的进展。因此，当前的研究需要从单变量分析转向阐明器官间通讯的时空动态，从而促进骨骼和心血管综合保护的精确治疗策略的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolism: clinical and experimental 医学-内分泌学与代谢

CiteScore

18.90

自引率

3.10%

发文量

310

审稿时长

16 days

期刊介绍： Metabolism upholds research excellence by disseminating high-quality original research, reviews, editorials, and commentaries covering all facets of human metabolism. Consideration for publication in Metabolism extends to studies in humans, animal, and cellular models, with a particular emphasis on work demonstrating strong translational potential. The journal addresses a range of topics, including: - Energy Expenditure and Obesity - Metabolic Syndrome, Prediabetes, and Diabetes - Nutrition, Exercise, and the Environment - Genetics and Genomics, Proteomics, and Metabolomics - Carbohydrate, Lipid, and Protein Metabolism - Endocrinology and Hypertension - Mineral and Bone Metabolism - Cardiovascular Diseases and Malignancies - Inflammation in metabolism and immunometabolism