Accurate interpretation of inosines in RNAs: recognized as G is more than basepairing with C.

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2025-06-21 DOI:10.1080/17501911.2025.2523237

Yuange Duan

引用次数: 0

Abstract

Adenosine-to-inosine (A-to-I) mRNA editing epigenetically mimics A-to-G mutations. While literatures usually state "inosines are recognized as guanosines," sometimes we also see expressions like "inosines basepair with cytosines." In this article, I stress that the two expressions are not equivalent at all for the following reasons. (1) inosines are recognized as guanosines only when located in mRNAs, not tRNAs; (2) even when being recognized as guanosines, inosines can basepair with cytosine and uracil; (3) when inosine pairs with cytosine, the basepairing efficiency differs from G:C pairing. Therefore, we should be cautious when introducing A-to-I RNA editing. "inosines basepair with cytosines" is an inaccurate or incomplete interpretation and should be corrected as "inosines in mRNAs are recognized as guanosines."

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准确解释rna中的肌苷：识别为G的不仅仅是与C进行碱基修复。

腺苷-肌苷（A-to-I） mRNA编辑在表观遗传学上模拟了A-to-G突变。虽然文献中通常说“肌苷被认为是鸟苷”，但有时我们也会看到“肌苷与胞嘧啶碱基对”这样的表达。在本文中，我强调这两个表达式完全不相等，原因如下。(1)肌苷只有在mrna中才能被识别为鸟苷，而不是trna；(2)肌苷即使被识别为鸟苷，也可以与胞嘧啶和尿嘧啶碱基配对；(3)肌苷与胞嘧啶配对时，碱基修复效率不同于G:C配对。因此，我们在引入A-to-I RNA编辑时应该谨慎。“肌苷与胞嘧啶碱基对”是一种不准确或不完整的解释，应更正为“mrna中的肌苷被认为是鸟苷”。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.