Updates on Tau-Related Drug Targets and Potential Disease-Modifying Therapies for Alzheimer's Disease.

IF 4.7 2区医学 Q1 PATHOLOGY

American Journal of Pathology Pub Date : 2025-06-19 DOI:10.1016/j.ajpath.2025.05.020

Anabela Djurovic-Topalovic, Natalie G Horgan, Jessica S Fortin

引用次数: 0

Abstract

Alzheimer's disease (AD) is a chronic, multifactorial neurodegenerative disease affecting a large proportion of the elderly population with detrimental psychological and socioeconomic impacts. This review starts with a brief overview of the molecular aspects of AD. It aims to provide recent updates on several potential protein targets studied as valid therapeutic approaches such as Bassoon protein, triggering receptor expressed on myeloid cells 2 (TREM2), phosphorylated tau (chimeric molecules DEPTAC and PhosTAC), O-GlcNAcase (OGA), and misfolded protein seeds. This review emphasizes the importance of pursuing a multifaceted approach to diversify and synergize the current AD pharmacotherapy.

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阿尔茨海默病tau相关药物靶点和潜在疾病改善疗法的最新进展。

阿尔茨海默病（AD）是一种慢性多因素神经退行性疾病，影响很大一部分老年人口，对心理和社会经济产生不利影响。本文首先简要介绍AD的分子机制。它旨在提供一些潜在的蛋白靶点的最新研究进展，如巴松管蛋白、髓细胞2上表达的触发受体（TREM2）、磷酸化tau（嵌合分子DEPTAC和PhosTAC）、O-GlcNAcase （OGA）和错误折叠的蛋白种子。这篇综述强调了寻求一个多方面的方法来多样化和协同当前AD药物治疗的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Pathology 医学-病理学

CiteScore

11.40

自引率

0.00%

发文量

178

审稿时长

30 days

期刊介绍： The American Journal of Pathology, official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease. The editors will consider basic, translational, and clinical investigations that directly address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiries. Examples of such foundational investigations include data mining, identification of biomarkers, molecular pathology, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence are also welcome. High priority is given to studies of human disease and relevant experimental models using molecular, cellular, and organismal approaches.