Towards Better and More Valid Zebrafish Models of Alzheimer's Disease: A Scientific Tribute to Prof. Mikhail I. Aghajanov

IF 4.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Neurochemistry Pub Date : 2025-06-23 DOI:10.1111/jnc.70090

Maria M. Kotova, Adam Michael Stewart, Artem Grigoryan, Sanobar Shariff, Foad Mirzaei, Burhan Kantawala, Karen Dilbaryan, Murilo S. de Abreu, David S. Galstryan, Jiahao Cui, Longen Yang, Konstantin B. Yenkoyan, Allan V. Kalueff

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Abstract

The most common form of dementia, Alzheimer's disease (AD) is a severely debilitating neurodegenerative disorder that afflicts over 50 million people globally. Despite extensive its research using various animal models, nearly all promising AD treatments have failed in clinical trials. Zebrafish (Danio rerio) have recently emerged as a valuable alternative to traditional (rodent) models of AD, possessing conserved neurotransmitter systems and disease pathways with humans, as well as orthologs for key genes associated with neurodegenerative disease. Here, we review recent advances and applications of zebrafish to study the pathogenesis of AD, and discuss the advantages, limitations, and potential future directions of research utilizing zebrafish AD models. This paper is dedicated to the late Professor Mikhail I. Aghajanov (1939–2024), a prominent Armenian neurochemist and a true crusader for fundamental AD research.

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迈向更好和更有效的阿尔茨海默病斑马鱼模型：对Mikhail I. Aghajanov教授的科学致敬

阿尔茨海默病（AD）是最常见的痴呆症形式，是一种严重使人衰弱的神经退行性疾病，全球有5000多万人患有此病。尽管使用各种动物模型进行了广泛的研究，但几乎所有有希望的阿尔茨海默病治疗都在临床试验中失败了。斑马鱼（Danio rerio）最近成为传统（啮齿动物）AD模型的有价值的替代品，具有保守的神经递质系统和与人类的疾病途径，以及与神经退行性疾病相关的关键基因的同源物。本文综述了斑马鱼在阿尔茨海默病发病机制研究中的最新进展和应用，并讨论了斑马鱼阿尔茨海默病模型的优势、局限性和潜在的未来研究方向。本文谨献给已故的Mikhail I. Aghajanov教授（1939-2024），他是一位杰出的亚美尼亚神经化学家，也是一位真正的AD基础研究的改革者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurochemistry 医学-神经科学

CiteScore

9.30

自引率

2.10%

发文量

181

审稿时长

2.2 months

期刊介绍： Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.