Effect of Oral Tranexamic Acid on Hair Melanin in Asian Women

IF 3.7 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2025-06-22 DOI:10.1155/dth/9071909

Tingwei Zhang, Jinglai Li, Yuexin Li, Zhenxi Guo, Xiangjie Qi

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Abstract

Introduction: Tranexamic acid (TXA) is widely used to treat melasma, but its potential effects on hair pigmentation remain unexplored. Concerns about hair whitening during TXA treatment have been raised, as it is often perceived as a sign of aging and may elicit negative emotional responses. This study aimed to evaluate the effects of oral TXA on hair melanin content and color.

Methods and Results: Seven middle-aged East Asian women completed a 3-month prospective observational study, taking 500-mg oral TXA daily, excluding menstruation periods. Hair samples were collected from 10 scalp regions before and after treatment. Melanin content was measured using liquid chromatography–tandem mass spectrometry, and hair color changes were assessed with a colorimeter. One participant was excluded due to hair dyeing during the study. After 3 months of TXA treatment, no statistically significant changes in hair melanin content or hair color were observed, even after accounting for individual differences.

Discussion: Oral TXA administered at 500 mg daily for 3 months did not significantly affect hair melanin content or color in middle-aged East Asian women. These findings provide reassurance for patients and clinicians regarding hair pigmentation during TXA treatment. Further research with diverse populations is recommended.

Trial Registration: Chinese Registry of Clinical Trials: ChiCTR2400092219

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口服氨甲环酸对亚洲女性头发黑色素的影响

简介：氨甲环酸（TXA）被广泛用于治疗黄褐斑，但其对头发色素沉着的潜在影响尚不清楚。在TXA治疗过程中，人们对头发变白的担忧已经提高，因为它通常被认为是衰老的标志，可能会引发负面的情绪反应。本研究旨在评价口服TXA对头发黑色素含量和颜色的影响。方法和结果：7名中年东亚妇女完成了一项为期3个月的前瞻性观察研究，每天口服500毫克TXA，不包括月经期。在治疗前后分别从10个头皮区域采集头发样本。用液相色谱-串联质谱法测定黑色素含量，用比色仪测定发色变化。一名参与者因染发而被排除在外。在TXA治疗3个月后，即使考虑到个体差异，也没有观察到头发黑色素含量或头发颜色的统计学显著变化。讨论：口服TXA，每日500毫克，连续3个月，对中年东亚妇女的头发黑色素含量或颜色没有显著影响。这些发现为TXA治疗期间的患者和临床医生提供了关于头发色素沉着的保证。建议对不同人群进行进一步研究。试验注册：中国临床试验注册中心：ChiCTR2400092219

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.