The Effect of Renal Denervation on Capillary Density in Patients With Uncontrolled Hypertension

IF 2 4区医学 Q3 HEMATOLOGY

Microcirculation Pub Date : 2025-06-22 DOI:10.1111/micc.70015

Lefki Nikolopoulou, Kyriakos Dimitriadis, Nikolaos Pyrpyris, Fotios Tatakis, Panagiotis Iliakis, Costas Thomopoulos, Dimitrios Konstantinidis, Loukianos Rallidis, Dimitrios Tousoulis, Konstantinos Tsioufis

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Abstract

Objective

Hypertension is related to the pathogenesis of microvascular dysfunction. Renal denervation is a guideline-endorsed intervention for the management of uncontrolled hypertension. However, the effect of renal denervation on skin capillary density, as assessed by nailfold capillaroscopy, is unknown.

Methods

Individuals with stage I/II uncontrolled hypertensions were enrolled and allocated to either undergo renal denervation or serve as controls. Nailfold capillaroscopy was performed at baseline and at 12 months. Furthermore, the albumin to creatinine ratio (ACR) and office/ambulatory blood pressure (BP) levels were monitored throughout the study.

Results

A total of 45 individuals (28 renal denervation, 17 control) were enrolled in our study. No difference was found in baseline capillary density. At 12 months, all patients had controlled BP, while the denervation arm had a significantly greater number of capillaries, compared with control (90.9 ± 14.0 vs. 82.5 ± 10.6 capillaries/mm²; p = 0.036). However, the change from baseline capillary density was not significantly different between groups (4.6 ± 6.1 vs. 1.39 ± 8.8 capillaries/mm²; p = 0.150). Moreover, the change of ACR was not different between groups (−2.7 ± 13.8 vs. 0.46 ± 5.2; p = 0.365).

Conclusion

In patients with uncontrolled stage I/II hypertension, renal denervation may have a beneficial effect on skin capillary density.

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未控制高血压患者肾去神经对毛细血管密度的影响

目的高血压与微血管功能障碍的发病机制有关。肾去神经是一种指南认可的干预措施，用于管理未控制的高血压。然而，肾去神经支配对皮肤毛细血管密度的影响，如甲襞毛细血管镜评估，是未知的。方法纳入I/II期未控制高血压患者，并将其分为两组，一组接受肾去神经支配治疗，另一组作为对照组。在基线和12个月时进行甲襞毛细血管镜检查。此外，在整个研究过程中监测白蛋白与肌酐比值（ACR）和办公室/动态血压（BP）水平。结果本研究共纳入45例患者，其中肾去神经组28例，对照组17例。基线毛细血管密度无差异。12个月时，所有患者的血压均得到控制，而去神经控制组的毛细血管数量明显多于对照组(90.9±14.0比82.5±10.6支/mm2；p = 0.036)。然而，与基线相比，两组间毛细血管密度的变化无显著差异(4.6±6.1 vs. 1.39±8.8毛细血管/mm2；p = 0.150)。此外，两组间ACR的变化无差异(- 2.7±13.8 vs. 0.46±5.2；p = 0.365)。结论对未控制的I/II期高血压患者，肾去神经支配可能对皮肤毛细血管密度有有益的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microcirculation 医学-外周血管病

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.