The human autophagy-initiating complexes ULK1C and PI3KC3-C1.

IF 4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biological Chemistry Pub Date : 2025-06-19 DOI:10.1016/j.jbc.2025.110391

Minghao Chen,James Hurley

引用次数: 0

Abstract

The unc-51-like kinase complex (ULK1C) and the class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) are the key regulators of macroautophagy initiation. Understanding the assembly and coordination of these two complexes is essential for deciphering their cellular regulation and targeting them for therapeutic enhancement. This review highlights recent advances in our understanding of the structural organization and activation mechanisms of ULK1C and PI3KC3-C1 at the molecular level and discusses their roles within the protein interaction network governing autophagy initiation.

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人自噬启动复合物ULK1C和PI3KC3-C1。

unc-51样激酶复合物（ULK1C）和III类磷脂酰肌醇3-激酶复合物I （PI3KC3-C1）是巨噬起始的关键调节因子。了解这两种复合物的组装和协调对于破译它们的细胞调控和靶向它们以提高治疗效果至关重要。这篇综述强调了我们在分子水平上对ULK1C和PI3KC3-C1的结构组织和激活机制的理解的最新进展，并讨论了它们在控制自噬起始的蛋白质相互作用网络中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biological Chemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

自引率

4.20%

发文量

1233

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