586-P: Effects of Replacing Diet Beverages with Water on Sustained Weight Loss and Type 2 Diabetes Remission—An 18-Month Randomized Clinical Trial

IF 7.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2025-06-20 DOI:10.2337/db25-586-p

MOHAMMAD MEHDI FARSHCHI NASR, AMENEH MADJD, HAMID R. FARSHCHI

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引用次数: 0

Abstract

Introduction and Objective: To evaluate the effects of replacing diet beverages (DBs) with water on the durability of weight loss and Type 2 Diabetes (T2D) remission over an 18-month weight management follow-up, which included a 6-month weight loss intervention and a subsequent 12-month weight maintenance program. Methods: 81 adult women with obesity or overweight and T2D, who usually consumed DBs in their diet, were randomly assigned to either substitute with water or continue drinking DBs 5 times/week after their lunch for the 18-month follow-up. Results: The participants who were randomly assigned were included in the study by using an intention-to-treat analysis. After the 18-month follow-up period, significant weight change (mean ± SD) in the water group was observed compared with the DBs group (-6.82 ± 2.73 kg vs. -4.85 ± 2.07kg) (P<0.001). Diabetes remission was achieved in 37/41 (90%) participants of the water group vs. 18/40 (45%) in the DBs group (P<0·0001). There were also significant changes in BMI, fasting plasma glucose, insulin levels, the homeostasis model assessment of insulin resistance, 2h postprandial glucose and serum triglyceride in the water group compared with DBs over the 18 months. Conclusion: Sustained replacement of DBs with water after the main meals in women with T2D may promote further weight reduction during an 18-month weight management program. It may also offer benefits in glycemic control and diabetes remission during the long-term diet plan. Disclosure M. Farshchi Nasr: None. A. Madjd: None. H.R. Farshchi: None.

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586-P：用水替代无糖饮料对持续减肥和2型糖尿病缓解的影响——一项为期18个月的随机临床试验

前言和目的：通过18个月的体重管理随访，评估用水代替无糖饮料对减肥和2型糖尿病（T2D）缓解的持久性的影响，其中包括6个月的体重减轻干预和随后的12个月的体重维持计划。方法：在18个月的随访中，81名肥胖或超重和T2D的成年女性通常在饮食中摄入DBs，她们被随机分配在午餐后用水代替或每周继续饮用5次DBs。结果：随机分配的参与者通过意向治疗分析纳入研究。在18个月的随访期后，与DBs组相比，水组的体重变化（平均±SD）显著（-6.82±2.73 kg vs -4.85±2.07kg）（P<0.001）。水组37/41（90%）的受试者糖尿病缓解，而DBs组18/40（45%）的受试者糖尿病缓解（P< 0.0001）。在18个月内，与DBs相比，水组的BMI、空腹血糖、胰岛素水平、胰岛素抵抗的稳态模型评估、餐后2小时血糖和血清甘油三酯也发生了显著变化。结论：在为期18个月的体重管理计划中，t2dm患者在正餐后持续用水替代DBs可能会促进体重进一步下降。在长期饮食计划中，它也可能对血糖控制和糖尿病缓解有好处。法什奇·纳斯尔：没有。答：没有。hr Farshchi：没有。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.