1373-P: Comparison of Characteristics among Individuals with Established vs. Newly Diagnosed Type 2 Diabetes during Ischemic Stroke Hospitalization—A Retrospective Cohort Study

IF 7.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2025-06-20 DOI:10.2337/db25-1373-p

CAICHEN ZHONG, SETH EMONT, LIN XIE, SUNDAY IKPE, ZHUN CAO, CRAIG B. LIPKIN, JOSHUA NOONE, EMILY ZACHERLE, CHALAK MUHAMMAD, ADAM DE HAVENON

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Abstract

Introduction and Objective: While newly diagnosed type 2 diabetes (T2D) at the time of a stroke is associated with poorer outcomes, characteristics comparing individuals diagnosed with T2D during stroke hospitalization and those with previously established T2D are not very well documented. This study aimed to examine the differences between the two groups. Methods: This retrospective, observational cohort study included adults hospitalized with an ischemic stroke from 07/01/2017 to 03/31/2023 utilizing the PINC AI™ Healthcare Database. Descriptive statistics were used to compare sociodemographic and clinical characteristics during and after hospitalization among individuals with a T2D diagnosis or anti-diabetic medication use before hospitalization (estT2D) and those with a discharge T2D diagnosis or laboratory values indicating T2D during hospitalization without prior evidence of T2D diagnosis (newT2D). Results: Compared to those with estT2D (N=103,060), individuals with newT2D (N=127,286) were younger (mean±SD: 68.6±12.5 vs 71.0±12.5 years), more likely to be male (55.4% vs 49.3%) and less likely to be enrolled in Medicare (61.8% vs 74.8%). Individuals with newT2D had a lower Charlson comorbidity index (CCI) score (mean±SD: 4.7±2.1 vs 5.5±2.4) and were more likely to be in the highest quintile of social vulnerability index (23.5% vs 21.3%). Individuals with newT2D also had longer lengths of stay (mean±SD: 5.6±5.7 vs 5.2±5.0 days), higher all-cause mortality during hospitalization (4.4% vs 3.6%) and lower all-cause 30-day readmission post discharge (11.8% vs 16.6%), compared to those with estT2D. Conclusion: Individuals hospitalized with stroke and newT2D had lower CCI scores and 30-day readmission rates compared to those with estT2D. They also experienced longer hospital stays and higher inpatient mortality. Our results highlight the need for early diagnosis and management of T2D. Disclosure C. Zhong: None. S. Emont: Other Relationship; Novo Nordisk. Employee; Premier, Inc. L. Xie: None. S. Ikpe: None. Z. Cao: Other Relationship; Novo Nordisk. Employee; Premier Inc. C.B. Lipkin: Employee; Premier Inc. J. Noone: Employee; Novo Nordisk. E. Zacherle: Employee; Novo Nordisk. C. Muhammad: Employee; Novo Nordisk. A. de Havenon: Consultant; Novo Nordisk.

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1373-P：缺血性卒中住院期间确诊与新诊断2型糖尿病患者特征的比较——一项回顾性队列研究

简介和目的：虽然卒中时新诊断的2型糖尿病（T2D）与较差的预后相关，但在卒中住院期间诊断为T2D的个体与先前诊断为T2D的个体的特征比较并没有很好的文献记录。这项研究旨在检查两组之间的差异。方法：这项回顾性、观察性队列研究纳入了2017年1月7日至2023年3月31日期间因缺血性卒中住院的成年人，使用PINC AI™医疗保健数据库。描述性统计用于比较T2D诊断或住院前使用抗糖尿病药物的个体（estT2D）和出院T2D诊断或住院期间没有T2D诊断证据的实验室值显示T2D的个体（newT2D）住院期间和住院后的社会人口学和临床特征。结果：与estT2D患者（N=103,060）相比，newT2D患者（N=127,286）更年轻（平均±SD: 68.6±12.5岁vs 71.0±12.5岁），更可能是男性（55.4% vs 49.3%），更不可能参加医疗保险（61.8% vs 74.8%）。newT2D患者的Charlson共病指数（CCI）得分较低（平均±SD: 4.7±2.1比5.5±2.4），且更有可能处于社会脆弱性指数的最高五分位数（23.5%比21.3%）。与estT2D患者相比，newT2D患者的住院时间更长（平均±SD: 5.6±5.7 vs 5.2±5.0天），住院期间的全因死亡率更高（4.4% vs 3.6%），出院后30天的全因再入院率更低（11.8% vs 16.6%）。结论：与estT2D患者相比，卒中合并newT2D住院患者CCI评分和30天再入院率较低。他们还经历了更长的住院时间和更高的住院死亡率。我们的研究结果强调了早期诊断和治疗T2D的必要性。钟：没有。S. Emont：其他关系；诺和诺德公司。员工;总理Inc .)谢林：没有。艾克：没有。曹中：其他关系；诺和诺德公司。员工;总理公司。C.B.利普金：雇员；总理公司。J. Noone：雇员；诺和诺德公司。E. Zacherle：雇员；诺和诺德公司。C. Muhammad：雇员；诺和诺德公司。A. de Havenon：顾问；诺和诺德公司。

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.