Epithelial-Mesenchymal Transition and Genetically Driven Early Tumor Seedings in Extraneural Metastasis of Glioblastoma.

IF 5.7 2区医学 Q1 Medicine

Cancer Science Pub Date : 2025-06-20 DOI:10.1111/cas.70126

Seisaku Kanayama, Kentaro Watanabe, Minoru Tanaka, Junko Takita, Tomoki Todo

引用次数: 0

Abstract

Genetic and cell biological analyses of this rare glioblastoma (GBM) case with rapidly progressive pleural metastasis revealed essential roles of epithelial-mesenchymal transition (EMT) and glioma stem-like cells (GSCs) in extraneural metastasis. Contrary to the common prediction, the metastatic lesion shared 73% of mutations and two fusion genes with the primary but not the recurrent tumor, indicating that extraneural metastasis occurs early in GBM progression. Functional assays using primary tumor-derived GSCs confirmed EMT-enhanced migratory behaviors. EMT and genetically driven early tumor seedings are crucial for extraneural GBM metastasis, emphasizing the need for further investigation into EMT pathways and GSC biology.

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胶质母细胞瘤神经外转移的上皮-间质转化和基因驱动的早期肿瘤播种。

对这例罕见的胶质母细胞瘤（GBM）伴快速进展性胸膜转移的遗传和细胞生物学分析揭示了上皮-间充质转化（EMT）和胶质瘤干细胞样细胞（GSCs）在神经外转移中的重要作用。与通常的预测相反，转移灶与原发肿瘤共享73%的突变和两个融合基因，而与复发肿瘤不相同，这表明神经外转移在GBM进展的早期就发生了。使用原发肿瘤来源的GSCs进行的功能分析证实了emt增强的迁移行为。EMT和基因驱动的早期肿瘤播种对于神经外GBM转移至关重要，强调需要进一步研究EMT途径和GSC生物学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Science ONCOLOGY-

CiteScore

9.90

自引率

3.50%

发文量

406

审稿时长

17 weeks

期刊介绍： Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.