Biomarkers in juvenile idiopathic arthritis: towards precision diagnosis and personalized therapy?

IF 5.2 2区 医学 Q1 RHEUMATOLOGY
Luciana Breda, Saverio La Bella, Armando Di Ludovico
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引用次数: 0

Abstract

Purpose to review: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, characterized by persistent joint inflammation with heterogeneous clinical subtypes. Early diagnosis and targeted treatment remain critical to improving long-term outcomes. In recent years, research has increasingly focused on the identification and validation of biomarkers to enhance diagnostic precision, predict disease course, and guide therapeutic decisions.

Recent findings: Calprotectin (S100A8/A9) is a pro-inflammatory protein complex released by activated neutrophils and monocytes. In JIA, serum and synovial fluid calprotectin levels correlate with disease activity and may outperform traditional markers like C-reactive protein and erythrocyte sedimentation rate. Evidence suggests that elevated calprotectin levels can predict flares and subclinical inflammation, making it a promising biomarker for monitoring and prognosis in JIA. Novel biomarkers including microRNAs show potential for differentiating disease subtypes and monitoring treatment response. Proteomic and metabolomic profiling are also uncovering candidates that may improve early diagnosis and personalized management.

Summary: Biomarkers have emerged as pivotal tools in the management of JIA, offering significant advantages in both therapeutic decision-making and long-term monitoring. In the future, a robust biomarker framework holds the potential to improve early diagnosis, guide personalized treatment strategies, and enhance outcome prediction-ultimately contributing to more effective and individualized care for patients with JIA.

青少年特发性关节炎的生物标志物:走向精确诊断和个性化治疗?
目的回顾:幼年特发性关节炎(JIA)是儿童中最常见的慢性风湿性疾病,其特征是持续的关节炎症,临床亚型异质性。早期诊断和靶向治疗对于改善长期预后仍然至关重要。近年来,研究越来越关注生物标志物的鉴定和验证,以提高诊断精度,预测疾病病程,指导治疗决策。Calprotectin (S100A8/A9)是一种由活化的中性粒细胞和单核细胞释放的促炎蛋白复合物。在JIA中,血清和滑液钙保护蛋白水平与疾病活动性相关,可能优于c反应蛋白和红细胞沉降率等传统标志物。有证据表明,钙保护蛋白水平升高可以预测急性发作和亚临床炎症,使其成为JIA监测和预后的有希望的生物标志物。包括microRNAs在内的新型生物标志物显示出区分疾病亚型和监测治疗反应的潜力。蛋白质组学和代谢组学分析也揭示了可能改善早期诊断和个性化管理的候选方法。摘要:生物标志物已成为JIA管理的关键工具,在治疗决策和长期监测方面都具有显著优势。在未来,一个强大的生物标志物框架有望改善早期诊断,指导个性化治疗策略,并增强结果预测,最终为JIA患者提供更有效和个性化的护理。
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来源期刊
Current opinion in rheumatology
Current opinion in rheumatology 医学-风湿病学
CiteScore
9.70
自引率
2.00%
发文量
89
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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