Clinical Perspectives on Amyloidosis in India: A Systematic Literature Review.

IF 2.7 4区 医学 Q2 HEMATOLOGY
Sumeet Mirgh, Uday Yanamandra, Ganesh K Vishvanathan, Sadashivudu Gundeti, Navin Khattry, M Joseph John, Pankaj Malhotra, Hari Menon, Satyaranjan Das, Reena Nair, Velu Nair, Tapan Saikia, Shaji K Kumar
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引用次数: 0

Abstract

Background: Amyloidosis is a condition characterized by deposition of insoluble protein fibrils in tissues, leading to diverse clinical manifestations. There is limited data addressing amyloidosis from India.

Objective: This study aims to systematically review the available clinical data on amyloidosis in India. By synthesizing existing knowledge, the review seeks to identify research gaps that require further exploration.

Methods: A systematic review was conducted using the PubMed database to identify English-language articles on amyloidosis from India published between 1959-2023. Additionally, abstracts from international conferences were analyzed. Data extracted were-type of amyloidosis, demographics, clinical presentation, diagnostic methods, and outcomes.

Results: The median age at presentation in Indian patients was approximately 10 years younger (50 years) compared to their counterparts in Western countries (60 years), with males comprising 70% of the cases. Renal involvement was the most common, with AA being more prevalent than AL amyloidosis, often secondary to tuberculosis. Cardiac involvement was second most common, affecting 40%-50% of patients. In patients with paraproteinemic neuropathies, AL amyloidosis accounts for the cause in 4% cases. Treatment of AL amyloidosis primarily involved chemotherapy and supportive care, with autologous transplantation underutilized due to resource limitations. Amongst localized amyloidosis, skin was the most common site (68% of all cases).

Conclusion: Amyloidosis in India remains a significant and often underdiagnosed condition, with varied presentations and causes. Most data come from retrospective studies, highlighting variability in presentation and outcomes. This review underscores the importance of understanding the disease burden and advancing research to improve outcomes in India.

印度淀粉样变性的临床观点:系统文献综述。
背景:淀粉样变性是一种以不溶性蛋白原纤维在组织中沉积为特征的疾病,导致多种临床表现。关于印度淀粉样变性的资料有限。目的:本研究旨在系统回顾现有的临床资料淀粉样变性在印度。通过综合现有知识,本综述试图找出需要进一步探索的研究空白。方法:使用PubMed数据库进行系统评价,以确定1959-2023年间发表的关于淀粉样变性的印度英语文章。此外,还分析了国际会议的摘要。提取的数据包括淀粉样变的类型、人口统计学、临床表现、诊断方法和结果。结果:印度患者的中位发病年龄(50岁)比西方国家(60岁)年轻约10岁,男性占70%。肾脏受累是最常见的,AA比AL淀粉样变更普遍,通常继发于肺结核。心脏受累是第二常见的,影响了40%-50%的患者。在副蛋白血症性神经病患者中,4%的病例是AL淀粉样变引起的。AL淀粉样变性的治疗主要包括化疗和支持治疗,由于资源限制,自体移植未得到充分利用。在局限性淀粉样变中,皮肤是最常见的部位(占所有病例的68%)。结论:淀粉样变在印度仍然是一个重要的和经常被诊断不足的条件,有不同的表现和原因。大多数数据来自回顾性研究,强调了表现和结果的可变性。这一综述强调了了解疾病负担和推进研究以改善印度结果的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.70
自引率
3.70%
发文量
1606
审稿时长
26 days
期刊介绍: Clinical Lymphoma, Myeloma & Leukemia is a peer-reviewed monthly journal that publishes original articles describing various aspects of clinical and translational research of lymphoma, myeloma and leukemia. Clinical Lymphoma, Myeloma & Leukemia is devoted to articles on detection, diagnosis, prevention, and treatment of lymphoma, myeloma, leukemia and related disorders including macroglobulinemia, amyloidosis, and plasma-cell dyscrasias. The main emphasis is on recent scientific developments in all areas related to lymphoma, myeloma and leukemia. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.
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