Killing hepatocellular carcinoma in the NAFLD/NASH stage: a comprehensive perspective on targeting regulated cell death.

IF 7 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-06-19 DOI:10.1038/s41420-025-02558-x

Jianxin Xi, Shuangyin Lei, Jie Chen, Jiahui Liu, Chenhao Shan, Xun Sun, Qianqian Zheng, Xiaoju Shi

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引用次数: 0

Abstract

Nonalcoholic steatohepatitis (NASH) has been identified as a significant risk factor contributing to the rising incidence of hepatocellular carcinoma (HCC). With the evolving epidemiological characteristics of NASH, the incidence of NASH-related HCC has increased substantially. Recent advances in the study of regulated cell death (RCD) mechanisms have uncovered their roles in the pathogenesis of NAFLD/NASH and associated HCC, offering novel insights and directions for targeted therapeutic strategies. Although numerous studies have highlighted the critical role of RCD mechanisms in NAFLD/NASH and related HCC, significant challenges remain in developing effective targeted therapies and translating them into clinical applications. This review aims to summarize the current progress in understanding the role of RCD in NAFLD/NASH and associated HCC, explore potential therapeutic strategies and clinical applications, and provide new perspectives and therapeutic targets for treating NAFLD/NASH. Ultimately, the goal is to control disease progression at the NAFLD/NASH stage and prevent its progression to HCC.

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杀伤NAFLD/NASH阶段的肝细胞癌：靶向调节细胞死亡的综合视角

非酒精性脂肪性肝炎（NASH）已被确定为导致肝细胞癌（HCC）发病率上升的一个重要危险因素。随着NASH流行病学特征的不断演变，NASH相关HCC的发生率大幅增加。调控细胞死亡（RCD）机制的最新研究进展揭示了它们在NAFLD/NASH及相关HCC发病机制中的作用，为靶向治疗策略提供了新的见解和方向。尽管许多研究都强调了RCD机制在NAFLD/NASH和相关HCC中的关键作用，但在开发有效的靶向治疗并将其转化为临床应用方面仍然存在重大挑战。本文旨在总结RCD在NAFLD/NASH及相关HCC中的作用，探讨潜在的治疗策略和临床应用，为NAFLD/NASH的治疗提供新的视角和治疗靶点。最终目标是控制NAFLD/NASH阶段的疾病进展，防止其发展为HCC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.